产品详情

  • 产品名称：Human TFAM (Transcription Factor A, Mitochondrial) Sandwich ELISA Kit Ready-To-Use (STJE0018866)

  • 产品型号：STJE0018866
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human TFAM (Transcription Factor A, Mitochondrial) Sandwich ELISA Kit Ready-To-Use (STJE0018866)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.109ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This TFAM Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: TFAM
Gene ID: 7019
Uniprot ID: TFAM_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity
Post Translational Modifications Phosphorylation by PKA within the HMG box 1 impairs DNA binding and promotes degradation by the AAA+ Lon protease.
Function Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA.
Protein Name Transcription Factor A - Mitochondrial
Mttfa
Mitochondrial Transcription Factor 1
Mttf1
Transcription Factor 6
Tcf-6
Transcription Factor 6-Like 2
Database Links Reactome: R-HSA-163282
Reactome: R-HSA-2151201
Cellular Localisation Mitochondrion
Mitochondrion Matrix
Mitochondrion Nucleoid
Alternative ELISA Names Transcription Factor A - Mitochondrial ELISA kit
Mttfa ELISA kit
Mitochondrial Transcription Factor 1 ELISA kit
Mttf1 ELISA kit
Transcription Factor 6 ELISA kit
Tcf-6 ELISA kit
Transcription Factor 6-Like 2 ELISA kit
TFAM ELISA kit
TCF6 ELISA kit
TCF6L2 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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