产品详情
简单介绍：
Anti-Caveolin 1 antibody (Internal) (STJ70728)
详情介绍：
| Host: | Goat |
| Applications: | Pep-ELISA/WB/IF/IHC/FC |
| Reactivity: | Human/Mouse/Rat/Dog/Pig |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Goat polyclonal antibody anti-Caveolin 1 (Internal) is suitable for use in ELISA, Western Blot, Immunofluorescence, Immunohistochemistry and Flow Cytometry research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | WB-0.001-0.01µg/ml IHC-2.5µg/ml IF-Strong expression of the protein seen in the Golgi and membranes of A431 cells and in the cytoplasm and Golgi of U2OS cells. 10µg/ml ELISA-antibody detection limit dilution 1:8000. |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | CAV1 |
| Gene ID: | 857 |
| Uniprot ID: | CAV1_HUMAN |
| Immunogen Region: | Internal |
| Accession Number: | NP_001744.2; NP_001166366.1 |
| Specificity: | This antibody is expected to recognize both reported isoforms (NP_001744.2; NP_001166366.1). Reported variants represent identical protein: NP_001166367.1, NP_001166368.1, NP_001166366.1. No cross-reactivity expected to Caveolin 2 and Caveolin 3 |
| Immunogen Sequence: | DELSEKQVYDAH |
| Post Translational Modifications | Ubiquitinated. Undergo monoubiquitination and multi- and/or polyubiquitination. Monoubiquitination of N-terminal lysines promotes integration in a ternary complex with UBXN6 and VCP which promotes oligomeric CAV1 targeting to lysosomes for degradation. Ubiquitinated by ZNRF1.leading to degradation and modulation of the TLR4-mediated immune response. The initiator methionine for isoform 2 is removed during or just after translation. The new N-terminal amino acid is then N-acetylated. Phosphorylated at Tyr-14 by ABL1 in response to oxidative stress. |
| Function | May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation. |
| Protein Name | Caveolin-1 |
| Database Links | Reactome: R-HSA-163560 Reactome: R-HSA-203615 Reactome: R-HSA-203641 Reactome: R-HSA-210991 Reactome: R-HSA-4641262 Reactome: R-HSA-5218920 Reactome: R-HSA-8980692 Reactome: R-HSA-9009391 Reactome: R-HSA-9013026 Reactome: R-HSA-9013106 Reactome: R-HSA-9013148 Reactome: R-HSA-9013149 Reactome: R-HSA-9013404 Reactome: R-HSA-9013405 Reactome: R-HSA-9013406 Reactome: R-HSA-9013407 Reactome: R-HSA-9013408 Reactome: R-HSA-9013409 Reactome: R-HSA-9013423 Reactome: R-HSA-9035034 Reactome: R-HSA-9617828 Reactome: R-HSA-9696264 Reactome: R-HSA-9696270 Reactome: R-HSA-9696273 Reactome: R-HSA-9735871 Reactome: R-HSA-9755779 |
| Cellular Localisation | Golgi Apparatus Membrane Peripheral Membrane Protein Cell Membrane Membrane Caveola Membrane Raft Golgi Apparatus Trans-Golgi Network Colocalized With Dpp4 In Membrane Rafts Potential Hairpin-Like Structure In The Membrane Membrane Protein Of Caveolae |
| Alternative Antibody Names | Anti-Caveolin-1 antibody Anti-CAV1 antibody Anti-CAV antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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