产品详情

  • 产品名称：Human SIRT5 (Sirtuin 5) Sandwich ELISA Kit (STJE0012178)

  • 产品型号：STJE0012178
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human SIRT5 (Sirtuin 5) Sandwich ELISA Kit (STJE0012178)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.067ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This SIRT5 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: SIRT5
Gene ID: 23408
Uniprot ID: SIR5_HUMAN
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity Widely expressed.
Post Translational Modifications
Function NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Activates SHMT2 by mediating its desuccinylation. Modulates ketogenesis through the desuccinylation and activation of HMGCS2. Has weak NAD-dependent protein deacetylase activity.however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX.
Protein Name Nad-Dependent Protein Deacylase Sirtuin-5 - Mitochondrial
Regulatory Protein Sir2 Homolog 5
Sir2-Like Protein 5
Database Links Reactome: R-HSA-2151201
Cellular Localisation Mitochondrion Matrix
Mitochondrion Intermembrane Space
Cytoplasm
Cytosol
Nucleus
Mainly Mitochondrial
Also Present Extramitochondrially
With A Fraction Present In The Cytosol And Very Small Amounts Also Detected In The Nucleus
Isoform 1: Cytoplasm
Mitochondrion
Isoform 2: Mitochondrion
Alternative ELISA Names Nad-Dependent Protein Deacylase Sirtuin-5 - Mitochondrial ELISA kit
Regulatory Protein Sir2 Homolog 5 ELISA kit
Sir2-Like Protein 5 ELISA kit
SIRT5 ELISA kit
SIR2L5 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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