产品详情

  • 产品名称：Anti-CHMP2A antibody (STJA0006759)

  • 产品型号：STJA0006759
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CHMP2A antibody (STJA0006759)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Charged multivesicular body protein 2a is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CHMP2A
Gene ID: 27243
Uniprot ID: CHM2A_HUMAN
Specificity: This antibody detects endogenous levels of CHMP2A at Human, Mouse
Immunogen: Synthesized peptide derived from human CHMP2A
Function Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Recruited to the reforming nuclear envelope (NE) during anaphase by LEMD2. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. (Microbial infection) The ESCRT machinery functions in topologically equivalent membrane fission events, such as the budding of enveloped viruses (HIV-1 and other lentiviruses). Involved in HIV-1 p6- and p9-dependent virus release.
Protein Name Charged Multivesicular Body Protein 2a
Chromatin-Modifying Protein 2a
Chmp2a
Putative Breast Adenocarcinoma Marker Bc-2
Vacuolar Protein Sorting-Associated Protein 2-1
Vps2-1
Hvps2-1
Database Links Reactome: R-HSA-162588
Reactome: R-HSA-1632852
Reactome: R-HSA-432720
Reactome: R-HSA-5620971
Reactome: R-HSA-917729
Reactome: R-HSA-9610379
Reactome: R-HSA-9615710
Reactome: R-HSA-9668328
Reactome: R-HSA-9679504
Reactome: R-HSA-9694676
Cellular Localisation Late Endosome Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Nucleus Envelope
Localizes To The Midbody Of Dividing Cells
Localized In Two Distinct Rings On Either Side Of The Fleming Body
Localizes To The Reforming Nuclear Envelope On Chromatin Disks During Late Anaphase
Alternative Antibody Names Anti-Charged Multivesicular Body Protein 2a antibody
Anti-Chromatin-Modifying Protein 2a antibody
Anti-Chmp2a antibody
Anti-Putative Breast Adenocarcinoma Marker Bc-2 antibody
Anti-Vacuolar Protein Sorting-Associated Protein 2-1 antibody
Anti-Vps2-1 antibody
Anti-Hvps2-1 antibody
Anti-CHMP2A antibody
Anti-BC2 antibody
Anti-CHMP2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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