产品详情

  • 产品名称：Human S1PR1 (Sphingosine 1 Phosphate Receptor 1) Sandwich ELISA Kit (STJE0011999)

  • 产品型号：STJE0011999
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human S1PR1 (Sphingosine 1 Phosphate Receptor 1) Sandwich ELISA Kit (STJE0011999)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.063ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This S1PR1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: S1PR1
Gene ID: 1901
Uniprot ID: S1PR1_HUMAN
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Endothelial cells, and to a lesser extent, in vascular smooth muscle cells, fibroblasts, melanocytes, and cells of epithelioid origin.
Post Translational Modifications S1P-induced endothelial cell migration requires the PKB/AKT1-mediated phosphorylation of the third intracellular loop at the Thr-236 residue. Palmitoylated by ZDHHC5. Palmitoylation is required for targeting to plasma membrane, enabling G(i) coupling.
Function G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodsia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis. Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury.
Protein Name Sphingosine 1-Phosphate Receptor 1
S1p Receptor 1
S1p1
Endothelial Differentiation G-Protein Coupled Receptor 1
Sphingosine 1-Phosphate Receptor Edg-1
S1p Receptor Edg-1
Cd Antigen Cd363
Database Links Reactome: R-HSA-419408
Reactome: R-HSA-6785807
Reactome: R-HSA-9679191
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Endosome
Membrane Raft
Recruited To Caveolin-Enriched Plasma Membrane Microdomains In Response To Oxidized 1-Palmitoyl-2-Arachidonoyl-Sn-Glycero-3-Phosphocholine
Ligand Binding Leads To Receptor Internalization
Alternative ELISA Names Sphingosine 1-Phosphate Receptor 1 ELISA kit
S1p Receptor 1 ELISA kit
S1p1 ELISA kit
Endothelial Differentiation G-Protein Coupled Receptor 1 ELISA kit
Sphingosine 1-Phosphate Receptor Edg-1 ELISA kit
S1p Receptor Edg-1 ELISA kit
Cd Antigen Cd363 ELISA kit
S1PR1 ELISA kit
CHEDG1 ELISA kit
EDG1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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