产品详情

  • 产品名称：Anti-CAPN1 antibody (Internal) (STJ72962)

  • 产品型号：STJ72962-100
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CAPN1 antibody (Internal) (STJ72962)
详情介绍：
Host: Goat
Applications: Pep-ELISA/WB/IHC
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-CAPN1 (Internal) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: WB-0.3-1µg/ml
IHC-5µg/ml
ELISA-antibody detection limit dilution 1:32000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: CAPN1
Gene ID: 823
Uniprot ID: CAN1_HUMAN
Immunogen Region: Internal
Accession Number: NP_005177.2
Specificity: Reported variants represent identical protein: NP_001185797.1, NP_005177.2, NP_001185798.1.
Immunogen Sequence: SEKSAGTVELDD
Post Translational Modifications Undergoes calcium-induced successive autoproteolytic cleavages that generate a membrane-bound 78 kDa active form and an intracellular 75 kDa active form. Calpastatin reduces with high efficiency the transition from 78 kDa to 75 kDa calpain forms.
Function Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves CTBP1 at 'Asn-375', 'Gly-387' and 'His-409'. Cleaves and activates caspase-7 (CASP7).
Protein Name Calpain-1 Catalytic Subunit
Calcium-Activated Neutral Proteinase 1
Canp 1
Calpain Mu-Type
Calpain-1 Large Subunit
Cell Proliferation-Inducing Gene 30 Protein
Micromolar-Calpain
Mucanp
Database Links Reactome: R-HSA-1474228
Reactome: R-HSA-6798695
Reactome: R-HSA-6809371
Reactome: R-HSA-8862803
Cellular Localisation Cytoplasm
Cell Membrane
Translocates To The Plasma Membrane Upon Ca(2+) Binding
In Granular Keratinocytes And In Lower Corneocytes
Colocalizes With Flg And Flg2
Alternative Antibody Names Anti-Calpain-1 Catalytic Subunit antibody
Anti-Calcium-Activated Neutral Proteinase 1 antibody
Anti-Canp 1 antibody
Anti-Calpain Mu-Type antibody
Anti-Calpain-1 Large Subunit antibody
Anti-Cell Proliferation-Inducing Gene 30 Protein antibody
Anti-Micromolar-Calpain antibody
Anti-Mucanp antibody
Anti-CAPN1 antibody
Anti-CANPL1 antibody
Anti-PIG30 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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