产品详情

  • 产品名称：Anti-CEP164 antibody (STJA0006757)

  • 产品型号：STJA0006757
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CEP164 antibody (STJA0006757)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Centrosomal protein of 164 kDa is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CEP164
Gene ID: 22897
Uniprot ID: CE164_HUMAN
Specificity: This antibody detects endogenous levels of CEP164 at Human
Immunogen: Synthesized peptide derived from human CEP164
Post Translational Modifications Phosphorylation at Ser-186 is induced upon DNA-damage caused by treatment with IR irradiation, UV irradiation, hydroxyurea or amphidicolin. Also MDC1-mediated chromatin remodeling is critical for DNA damage-induced phosphorylation.
Function Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1.
Protein Name Centrosomal Protein Of 164 Kda
Cep164
Database Links Reactome: R-HSA-2565942
Reactome: R-HSA-380259
Reactome: R-HSA-380270
Reactome: R-HSA-380284
Reactome: R-HSA-380320
Reactome: R-HSA-5620912
Reactome: R-HSA-8854518
Cellular Localisation Cytoplasm
Cytoskeleton
Microtubule Organizing Center
Centrosome
Centriole
Nucleus
Localizes Specifically To Very Distally Located Appendage Structures On The Mature Centriole From Which Initiate Pc Formation
Persisted At Centrioles Throughout Mitosis
Expressed In Chromatin-Enriched Nuclear Fraction Of Hela Cells
In Response To Dna Damage
It Translocates To Nuclear Foci That Contain The Dna Damage Response Proteins Kat5/Tip60 And Chek1
Alternative Antibody Names Anti-Centrosomal Protein Of 164 Kda antibody
Anti-Cep164 antibody
Anti-CEP164 antibody
Anti-KIAA1052 antibody
Anti-NPHP15 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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