产品详情

  • 产品名称：Human RPS6Ka1 (Ribosomal Protein S6 Kinase Alpha 1) Sandwich ELISA Kit (STJE0011943)

  • 产品型号：STJE0011943
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human RPS6Ka1 (Ribosomal Protein S6 Kinase Alpha 1) Sandwich ELISA Kit (STJE0011943)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.117ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This RPS6Ka1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: RPS6KA1
Gene ID: 6195
Uniprot ID: KS6A1_HUMAN
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity
Post Translational Modifications Activated by phosphorylation at Ser-221 by PDPK1. Autophosphorylated on Ser-380, as part of the activation process. May be phosphorylated at Thr-359 and Ser-363 by MAPK1/ERK2 and MAPK3/ERK1. N-terminal myristoylation results in an activated kinase in the absence of added growth factors.
Function Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes. In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP. Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity. Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the pre-initiation complex. In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation. Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway. Also involved in feedback regulation of mTORC1 and mTORC2 by phosphorylating DEPTOR. Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function. Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4). Mediates induction of hepatocyte prolifration by TGFA through phosphorylation of CEBPB. Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocations to the nucleus and inhibition of G1 progression. Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration. In response to mTORC1 activation, phosphorylates EIF4B at 'Ser-406' and 'Ser-422' which stimulates bicarbonate cotransporter SLC4A7 mRNA translation, increasing SLC4A7 protein abundance and function. (Microbial infection) Promotes the late transcription and translation of viral lytic genes during Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, when constitutively activated.
Protein Name Ribosomal Protein S6 Kinase Alpha-1
S6k-Alpha-1
90 Kda Ribosomal Protein S6 Kinase 1
P90-Rsk 1
P90rsk1
P90s6k
Map Kinase-Activated Protein Kinase 1a
Mapk-Activated Protein Kinase 1a
Mapkap Kinase 1a
Mapkapk-1a
Ribosomal S6 Kinase 1
Rsk-1
Database Links Reactome: R-HSA-198753
Reactome: R-HSA-199920
Reactome: R-HSA-2559582
Reactome: R-HSA-437239
Reactome: R-HSA-442742
Reactome: R-HSA-444257
Reactome: R-HSA-881907
Cellular Localisation Nucleus
Cytoplasm
Alternative ELISA Names Ribosomal Protein S6 Kinase Alpha-1 ELISA kit
S6k-Alpha-1 ELISA kit
90 Kda Ribosomal Protein S6 Kinase 1 ELISA kit
P90-Rsk 1 ELISA kit
P90rsk1 ELISA kit
P90s6k ELISA kit
Map Kinase-Activated Protein Kinase 1a ELISA kit
Mapk-Activated Protein Kinase 1a ELISA kit
Mapkap Kinase 1a ELISA kit
Mapkapk-1a ELISA kit
Ribosomal S6 Kinase 1 ELISA kit
Rsk-1 ELISA kit
RPS6KA1 ELISA kit
MAPKAPK1A ELISA kit
RSK1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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