产品详情

  • 产品名称：Anti-CD41/ITGA2B antibody [HIP8] {PE/Cyanine7} (STJA0000453)

  • 产品型号：STJA0000453
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CD41/ITGA2B antibody [HIP8] {PE/Cyanine7} (STJA0000453)
详情介绍：
Host: Mouse
Applications: FC
Reactivity: Human
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Integrin alpha-IIb is suitable for use in Flow Cytometry research applications.
Clonality: Monoclonal
Clone ID: HIP8
Conjugation: PE/Cyanine7
Isotype: IgG1k
Formulation: PBS with 0.05% Proclin300, 1% BSA
Storage Instruction: Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product.
Gene Symbol: ITGA2B
Gene ID: 3674
Uniprot ID: ITA2B_HUMAN
Tissue Specificity Isoform 1 and isoform 2 are expressed in platelets and megakaryocytes, but not in reticulocytes. Not detected in Jurkat, nor in U937 cell lines. Isoform 3 is expressed in prostate adenocarcinoma, as well as in several erythroleukemia, prostate adenocarcinoma and melanoma cell lines, including PC-3, DU-145, HEL, WM983A, WM983B and WM35. Not detected in platelets, nor in normal prostate (at protein level).
Function Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
Protein Name Integrin Alpha-Iib
Gpalpha Iib
Gpiib
Platelet Membrane Glycoprotein Iib
Cd Antigen Cd41 Cleaved Into - Integrin Alpha-Iib Heavy Chain - Integrin Alpha-Iib Light Chain - Form 1 - Integrin Alpha-Iib Light Chain - Form 2
Database Links Reactome: R-HSA-114608
Reactome: R-HSA-216083
Reactome: R-HSA-3000178
Reactome: R-HSA-354192
Reactome: R-HSA-354194
Reactome: R-HSA-372708
Reactome: R-HSA-445144
Reactome: R-HSA-5674135
Reactome: R-HSA-6802946
Reactome: R-HSA-6802948
Reactome: R-HSA-6802952
Reactome: R-HSA-6802955
Reactome: R-HSA-8936459
Reactome: R-HSA-9649948
Reactome: R-HSA-9656223
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Integrin Alpha-Iib antibody
Anti-Gpalpha Iib antibody
Anti-Gpiib antibody
Anti-Platelet Membrane Glycoprotein Iib antibody
Anti-Cd Antigen Cd41 Cleaved Into - Integrin Alpha-Iib Heavy Chain - Integrin Alpha-Iib Light Chain - Form 1 - Integrin Alpha-Iib Light Chain - Form 2 antibody
Anti-ITGA2B antibody
Anti-GP2B antibody
Anti-ITGAB antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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