产品详情
简单介绍:
Anti-CD303/CLEC4C antibody [201A] {FITC} (STJA0000948)
详情介绍:
Host: | Mouse |
Applications: | FC |
Reactivity: | Human |
Note: | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Short Description: | Mouse monoclonal antibody anti-C-type lectin domain family 4 member C is suitable for use in Flow Cytometry research applications. |
Clonality: | Monoclonal |
Clone ID: | 201A |
Conjugation: | FITC |
Isotype: | IgG2ak |
Formulation: | PBS with 0.05% Proclin300, 1% BSA |
Storage Instruction: | Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product. |
Gene Symbol: | CLEC4C |
Gene ID: | 170482 |
Uniprot ID: | CLC4C_HUMAN |
Tissue Specificity | Expressed in plasmacytoid dendritic cells (PDCs). Constitutively expressed in immature monocyte-derived dendritic cells (iMDDC) and is significantly down-regulated upon maturation with LPS but not with TNF-alpha. |
Function | Lectin-type cell surface receptor which may play a role in antigen capturing by dendritic cells. Specifically recognizes non-sialylated galactose-terminated biantennary glycans containing the trisaccharide epitope Gal(beta1-3/4)GlcNAc(beta1-2)Man. Binds to serum IgG. Efficiently targets ligand into antigen-processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium. |
Protein Name | C-Type Lectin Domain Family 4 Member C Blood Dendritic Cell Antigen 2 Bdca-2 C-Type Lectin Superfamily Member 7 Dendritic Lectin Cd Antigen Cd303 |
Database Links | Reactome: R-HSA-5621480 Reactome: R-HSA-6798695 |
Cellular Localisation | Cell Membrane Single-Pass Type Ii Membrane Protein |
Alternative Antibody Names | Anti-C-Type Lectin Domain Family 4 Member C antibody Anti-Blood Dendritic Cell Antigen 2 antibody Anti-Bdca-2 antibody Anti-C-Type Lectin Superfamily Member 7 antibody Anti-Dendritic Lectin antibody Anti-Cd Antigen Cd303 antibody Anti-CLEC4C antibody Anti-BDCA2 antibody Anti-CLECSF11 antibody Anti-CLECSF7 antibody Anti-DLEC antibody Anti-HECL antibody Anti-UNQ9361 antibody Anti-PRO34150 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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