产品详情

  • 产品名称：Anti-CD19 antibody (96-281aa) [ZR212] (STJ180396)

  • 产品型号：STJ180396
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CD19 antibody (96-281aa) [ZR212] (STJ180396)
详情介绍：
Host: Rabbit
Applications: IHC-P
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit monoclonal antibody anti-CD19 (96-281aa) is suitable for use in Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: ZR212
Conjugation: Unconjugated
Isotype: IgG
Formulation: Tris-HCI buffer containing stabilizing protein (BSA) and <0.1% proclin<="" td="">
Purification: Affinity purified
Dilution Range: 1:100‐200
Storage Instruction: Store at 2‐8°C for up to 24 months. Predilute: Ready to use, no reconstitution necessary. Concentrate: Use dilution range and appropriate lab‐standardized diluent. Stability after dilution: 7 days at 24°C, 3 months at 2‐8°C, 6months at ‐20°C.
Gene Symbol: CD19
Gene ID: 930
Uniprot ID: CD19_HUMAN
Immunogen Region: 96-281aa
Specificity: Positive control: Lymph node or tonsil
Immunogen: Recombinant fragment of human CD19 protein (around aa 96-281)
Tissue Specificity Detected on marginal zone and germinal center B cells in lymph nodes. Detected on blood B cells (at protein level).
Post Translational Modifications Phosphorylated on tyrosine following B-cell activation. Phosphorylated on tyrosine residues by LYN. Tyrosine residues are phosphorylated sequentially after activation of the B cell receptor. Phosphorylation of Tyr-531 is extremely rapid, followed by phosphorylation at Tyr-409. In contrast, phosphorylation of Tyr-500 appears more slowly and is more transient, returning rapidly to basal levels.
Function Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens. Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores. Is not required for early steps during B cell differentiation in the blood marrow. Required for normal differentiation of B-1 cells. Required for normal B cell differentiation and proliferation in response to antigen challenges. Required for normal levels of serum immunoglobulins, and for production of high-affinity antibodies in response to antigen challenge.
Protein Name B-Lymphocyte Antigen Cd19
B-Lymphocyte Surface Antigen B4
Differentiation Antigen Cd19
T-Cell Surface Antigen Leu-12
Cd Antigen Cd19
Database Links Reactome: R-HSA-1257604
Reactome: R-HSA-198933
Reactome: R-HSA-2219530
Reactome: R-HSA-6811558
Reactome: R-HSA-977606
Reactome: R-HSA-983695
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Membrane Raft
Alternative Antibody Names Anti-B-Lymphocyte Antigen Cd19 antibody
Anti-B-Lymphocyte Surface Antigen B4 antibody
Anti-Differentiation Antigen Cd19 antibody
Anti-T-Cell Surface Antigen Leu-12 antibody
Anti-Cd Antigen Cd19 antibody
Anti-CD19 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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