产品详情

  • 产品名称：Human IL4R (Interleukin 4 Receptor) Sandwich ELISA Kit (STJE0009943)

  • 产品型号：STJE0009943
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human IL4R (Interleukin 4 Receptor) Sandwich ELISA Kit (STJE0009943)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 5.8pg/mL
Detection Limit: 15.6-1000pg/mL
Short Description: This IL4R Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: IL4R
Gene ID: 3566
Uniprot ID: IL4RA_HUMAN
Sample Type: serum, plasma, tissue homogenates or other biological fluids.
Tissue Specificity Isoform 1 and isoform 2 are highly expressed in activated T-cells.
Post Translational Modifications On IL4 binding, phosphorylated on C-terminal tyrosine residues. Phosphorylation on any one of tyrosine residues, Tyr-575, Tyr-603 or Tyr-631, is required for STAT6-induced gene induction. The soluble form (sIL4R/IL4BP) can also be produced by proteolytic cleavage at the cell surface (shedding) by a metalloproteinase.
Function Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells.
Protein Name Interleukin-4 Receptor Subunit Alpha
Il-4 Receptor Subunit Alpha
Il-4r Subunit Alpha
Il-4r-Alpha
Il-4ra
Cd Antigen Cd124 Cleaved Into - Soluble Interleukin-4 Receptor Subunit Alpha
Soluble Il-4 Receptor Subunit Alpha
Soluble Il-4r-Alpha
Sil4ralpha/Prot
Il-4-Binding Protein
Il4-Bp
Database Links Reactome: R-HSA-6785807
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Isoform 2: Secreted
Alternative ELISA Names Interleukin-4 Receptor Subunit Alpha ELISA kit
Il-4 Receptor Subunit Alpha ELISA kit
Il-4r Subunit Alpha ELISA kit
Il-4r-Alpha ELISA kit
Il-4ra ELISA kit
Cd Antigen Cd124 Cleaved Into - Soluble Interleukin-4 Receptor Subunit Alpha ELISA kit
Soluble Il-4 Receptor Subunit Alpha ELISA kit
Soluble Il-4r-Alpha ELISA kit
Sil4ralpha/Prot ELISA kit
Il-4-Binding Protein ELISA kit
Il4-Bp ELISA kit
IL4R ELISA kit
IL4RA ELISA kit
582J2.1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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