产品详情

  • 产品名称：Human RSPO1 (R-Spondin 1) Sandwich ELISA Kit (STJE0011948)

  • 产品型号：STJE0011948
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human RSPO1 (R-Spondin 1) Sandwich ELISA Kit (STJE0011948)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 5.8pg/mL
Detection Limit: 15.6-1000pg/mL
Short Description: This RSPO1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: RSPO1
Gene ID: 284654
Uniprot ID: RSPO1_HUMAN
Sample Type: serum, plasma, tissue homogenates or other biological fluids.
Tissue Specificity Abundantly expressed in adrenal glands, ovary, testis, thyroid and trachea but not in bone marrow, spinal cord, stomach, leukocytes colon, small intestine, prostate, thymus and spleen.
Post Translational Modifications
Function Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination. Regulates Wnt signaling by antagonizing DKK1/KREM1-mediated internalization of LRP6 through an interaction with KREM1.
Protein Name R-Spondin-1
Roof Plate-Specific Spondin-1
Hrspo1
Database Links Reactome: R-HSA-4641263
Cellular Localisation Secreted
Nucleus
Seems To Mainly Localize To Nucleoli
Alternative ELISA Names R-Spondin-1 ELISA kit
Roof Plate-Specific Spondin-1 ELISA kit
Hrspo1 ELISA kit
RSPO1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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