产品详情

  • 产品名称：Anti-CEMIP antibody (180-420) (STJ116320)

  • 产品型号：STJ116320
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CEMIP antibody (180-420) (STJ116320)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CEMIP (180-420) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CEMIP
Gene ID: 57214
Uniprot ID: CEMIP_HUMAN
Immunogen Region: 180-420
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 180-420 of human CEMIP (NP_001280227.1).
Immunogen Sequence: FERSWGHRGVIVHVIDPKSG TVIHSDRFDTYRSKKESERL VQYLNAVPDGRILSVAVNDE GSRNLDDMARKAMTKLGSKH FLHLGFRHPWSFLTVKGNPS SSVEDHIEYHGHRGSAAARV FKLFQTEHGEYFNVSLSSEW VQDVEWTEWFDHDKVSQTKG GEKISDLWKAHPGKICNRPI DIQATTMDGVNLSTEVVYKK GQDYRFACYDRGRACRSYRV RFLCGKPVRPKLTVTIDTN
Tissue Specificity Expressed in dermal and in synovial fibroblasts. Strongly expressed in gastric cancers compared with the paired normal tissues. Strongly expressed in both ductal carcinoma and invasive breast cancer cells compared with benign epithelial cells (at protein level). Strongly expressed in brain, placenta, prostate, breast, lung and testis. Expressed in fibroblasts, epithelial cells and cancer cells. In ear, it is specifically expressed in inner ear. Expressed in cochlea and vestibule tissues. Strongly expressed in gastric cancers compared with the paired normal tissues. Strongly expressed in colon adenocarcinomas compared with normal colonic mucosas. Strongly expressed in breast cancer as compared to normal breast tissue.
Post Translational Modifications N-glycosylated.glycosylation is not necessary for HA-binding.
Function Mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid. Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product, a process that may occur through rapid vesicle endocytosis and recycling without intracytoplasmic accumulation or digestion in lysosomes. Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epithelial-mesenchymal transition (EMT), and hence tumor cell growth, invasion and cancer dissemination. In collaboration with HSPA5/BIP, promotes cancer cell migration in a calcium and PKC-dependent manner. May be involved in hearing.
Protein Name Cell Migration-Inducing And Hyaluronan-Binding Protein
Hyaluronan Binding Protein Involved In Hyaluronan Depolymerization
Database Links Reactome: R-HSA-2142850
Cellular Localisation Nucleus
Cytoplasm
Endoplasmic Reticulum
Cell Membrane
Membrane
Clathrin-Coated Pit
Secreted
Retained In The Endoplasmic Reticulum (Er) In A Hspa5/Bip-Dependent Manner
Colocalized With Clathrin Heavy Chain/Cltc In Clathrin-Coated Vesicles
Strongly Detected In The Cytoplasm Of Breast Carcinoma Cells
Whereas Poorly Detected In Adjacent Normal Epithelial Cells
Stromal Cells
Or Benign Breast Tissues
Localized In The Nucleus And Cytoplasm Of Colon Adenocarcinomas
Alternative Antibody Names Anti-Cell Migration-Inducing And Hyaluronan-Binding Protein antibody
Anti-Hyaluronan Binding Protein Involved In Hyaluronan Depolymerization antibody
Anti-CEMIP antibody
Anti-HYBID antibody
Anti-KIAA1199 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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