产品详情

  • 产品名称：Human RBM20 (RNA Binding Motif Protein 20) Sandwich ELISA Kit Ready-To-Use (STJE0018225)

  • 产品型号：STJE0018225
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human RBM20 (RNA Binding Motif Protein 20) Sandwich ELISA Kit Ready-To-Use (STJE0018225)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.121ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This RBM20 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: RBM20
Gene ID: 282996
Uniprot ID: RBM20_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Mainly expressed in the heart. Also expressed in skeletal muscle tissues, ovary, small intestine and colon.
Post Translational Modifications Phosphorylation regulates the subcellular localization. Phosphorylation of Ser-635 and Ser-637 in the RS (arginine/serine-rich) region promotes nuclear localization of the protein. In contrast, phosphorylation of the C-terminal disordered region promotes localization to cytoplasmic ribonucleoprotein granules.
Function RNA-binding protein that acts as a regulator of mRNA splicing of a subset of genes encoding key structural proteins involved in cardiac development, such as TTN (Titin), CACNA1C, CAMK2D or PDLIM5/ENH. Acts as a repressor of mRNA splicing: specifically binds the 5'UCUU-3' motif that is predominantly found within intronic sequences of pre-mRNAs, leading to the exclusion of specific exons in target transcripts. RBM20-mediated exon skipping is hormone-dependent and is essential for TTN isoform transition in both cardiac and skeletal muscles. RBM20-mediated exon skipping of TTN provides substrates for the formation of circular RNA (circRNAs) from the TTN transcripts. Together with RBM24, promotes the expression of short isoforms of PDLIM5/ENH in cardiomyocytes.
Protein Name Rna-Binding Protein 20
Rna-Binding Motif Protein 20
Database Links
Cellular Localisation Nucleus
Cytoplasm
Cytoplasmic Ribonucleoprotein Granule
The Active Form That Regulates Alternative Splicing Localizes To The Nucleus
Also Localizes To Cytoplasmic Ribonucleoprotein Granules
Localization To Cytoplasmic Ribonucleoprotein Granules Plays An Important Regulatory Role
Subcellular Localization Is Regulated By Phosphorylation Of Different Parts Of The Protein: While Phosphorylation Of The Rs (Arginine/Serine-Rich) Region Promotes Nuclear Localization
Phosphorylation Of The C-Terminal Disordered Region Promotes Localization To Cytoplasmic Ribonucleoprotein Granules
Alternative ELISA Names Rna-Binding Protein 20 ELISA kit
Rna-Binding Motif Protein 20 ELISA kit
RBM20 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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