产品详情

  • 产品名称：Anti-CALCOCO2 antibody (1-283) [S5283RM] (STJ11105283)

  • 产品型号：STJ11105283
  • 产品厂商：ST john's laboratory
  • 产品文档：
你添加了1件商品 查看购物车
简单介绍：
Anti-CALCOCO2 antibody (1-283) [S5283RM] (STJ11105283)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit monoclonal antibody anti-Calcium-Binding And Coiled-Coil Domain-Containing Protein 2 (1-283) is suitable for use in Western Blot research applications.
Clonality: Monoclonal
Clone ID: S5283RM
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:1000-1:5000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CALCOCO2
Gene ID: 10241
Uniprot ID: CACO2_HUMAN
Immunogen Region: 1-283
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-283 of human NDP52 (NP_005822.1).
Immunogen Sequence: MEETIKDPPTSAVLLDHCHF SQVIFNSVEKFYIPGGDVTC HYTFTQHFIPRRKDWIGIFR VGWKTTREYYTFMWVTLPID LNNKSAKQQEVQFKAYYLPK DDEYYQFCYVDEDGVVRGAS IPFQFRPENEEDILVVTTQG EVEEIEQHNKELCKENQELK DSCISLQKQNSDMQAELQKK QEELETLQSINKKLELKVKE QKDYWETELLQLKEQNQKMS SENEKMGIRVDQLQAQLST
Tissue Specificity Expressed in all tissues tested with highest expression in skeletal muscle and lowest in brain.
Post Translational Modifications (Microbial infection) Cleaved by S.pyogenes SpeB protease.leading to its degradation. Degradation by SpeB prevents autophagy, promoting to S.pyogenes intracellular replication.
Function Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy. Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation. Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with MAP3LC3C. May play a role in ruffle formation and actin cytoskeleton organization and seems to negatively regulate constitutive secretion.
Protein Name Calcium-Binding And Coiled-Coil Domain-Containing Protein 2
Antigen Nuclear Dot 52 Kda Protein
Nuclear Domain 10 Protein Ndp52
Nuclear Domain 10 Protein 52
Nuclear Dot Protein 52
Cellular Localisation Cytoplasm
Perinuclear Region
Cytoskeleton
Cytoplasmic Vesicle
Autophagosome Membrane
Peripheral Membrane Protein
Localizes To Nuclear Dots
It Is Not A Nuclear Dot-Associated Protein But Localizes Predominantly In The Cytoplasm With A Coarse-Grained Distribution Preferentially Close To The Nucleus
Alternative Antibody Names Anti-Calcium-Binding And Coiled-Coil Domain-Containing Protein 2 antibody
Anti-Antigen Nuclear Dot 52 Kda Protein antibody
Anti-Nuclear Domain 10 Protein Ndp52 antibody
Anti-Nuclear Domain 10 Protein 52 antibody
Anti-Nuclear Dot Protein 52 antibody
Anti-CALCOCO2 antibody
Anti-NDP52 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
姓名：
电话：
您的需求：
 
网站地图