产品详情

  • 产品名称：Anti-CDK4 antibody [EP180] (STJ16101441)

  • 产品型号：STJ16101441-1
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CDK4 antibody [EP180] (STJ16101441)
详情介绍：
Host: Rabbit
Applications: IHC-P
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit monoclonal antibody anti-CDK4 is suitable for use in Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: EP180
Conjugation: Unconjugated
Isotype: IgG
Formulation: Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% sodium="" azide<="" td="">
Dilution Range: IHC-P 1:100-1:200
Storage Instruction: Store at 2-8°C upon receipt.
Gene Symbol: CDK4
Gene ID: 1019
Uniprot ID: CDK4_HUMAN
Immunogen: a synthetic peptide corresponding to residues of human CDK4 protein
Post Translational Modifications Phosphorylation at Thr-172 is required for enzymatic activity. Phosphorylated, in vitro, at this site by CCNH-CDK7, but, in vivo, appears to be phosphorylated by a proline-directed kinase. In the cyclin D-CDK4-CDKN1B complex, this phosphorylation and consequent CDK4 enzyme activity, is dependent on the tyrosine phosphorylation state of CDKN1B. Thus, in proliferating cells, CDK4 within the complex is phosphorylated on Thr-172 in the T-loop. In resting cells, phosphorylation on Thr-172 is prevented by the non-tyrosine-phosphorylated form of CDKN1B.
Function Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocations and activity of the cyclin D-CDK4 complex.
Protein Name Cyclin-Dependent Kinase 4
Cell Division Protein Kinase 4
Psk-J3
Database Links Reactome: R-HSA-187577
Reactome: R-HSA-2559580
Reactome: R-HSA-2559582
Reactome: R-HSA-2559585
Reactome: R-HSA-3214858
Reactome: R-HSA-381340
Reactome: R-HSA-69231
Reactome: R-HSA-75815
Reactome: R-HSA-8849470
Reactome: R-HSA-8878166
Reactome: R-HSA-912446
Reactome: R-HSA-9616222
Reactome: R-HSA-9630791
Reactome: R-HSA-9630794
Reactome: R-HSA-9632697
Reactome: R-HSA-9632700
Reactome: R-HSA-9661069
Reactome: R-HSA-9754119
Cellular Localisation Cytoplasm
Nucleus
Nucleus Membrane
Cytoplasmic When Non-Complexed
Forms A Cyclin D-Cdk4 Complex In The Cytoplasm As Cells Progress Through G(1) Phase
The Complex Accumulates On The Nuclear Membrane And Enters The Nucleus On Transition From G(1) To S Phase
Also Present In Nucleoli And Heterochromatin Lumps
Colocalizes With Rb1 After Release Into The Nucleus
Alternative Antibody Names Anti-Cyclin-Dependent Kinase 4 antibody
Anti-Cell Division Protein Kinase 4 antibody
Anti-Psk-J3 antibody
Anti-CDK4 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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