产品详情

  • 产品名称：Anti-CDH5 antibody (391-440 aa) (STJ97306)

  • 产品型号：STJ97306
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CDH5 antibody (391-440 aa) (STJ97306)
详情介绍：
Host: Rabbit
Applications: IF/WB/IHC/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Cadherin-5 (391-440 aa) is suitable for use in Immunofluorescence, Western Blot, Immunohistochemistry and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: IF 1:50-200
WB 1:500-2000
ELISA 1:10000-20000
IHC 1:50-300
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CDH5
Gene ID: 1003
Uniprot ID: CADH5_HUMAN
Immunogen Region: 391-440 aa
Specificity: VE-Cadherin Polyclonal Antibody detects endogenous levels of VE-Cadherin protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human CDH5 at the amino acid range 391-440
Post Translational Modifications Phosphorylated on tyrosine residues by KDR/VEGFR-2. Dephosphorylated by PTPRB. O-glycosylated.
Function Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells.cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 and PALS1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction.
Protein Name Cadherin-5
7b4 Antigen
Vascular Endothelial Cadherin
Ve-Cadherin
Cd Antigen Cd144
Database Links Reactome: R-HSA-418990
Reactome: R-HSA-5218920
Cellular Localisation Cell Junction
Cell Membrane
Single-Pass Type I Membrane Protein
Found At Cell-Cell Boundaries And Probably At Cell-Matrix Boundaries
Krit1 And Cdh5 Reciprocally Regulate Their Localization To Endothelial Cell-Cell Junctions
Alternative Antibody Names Anti-Cadherin-5 antibody
Anti-7b4 Antigen antibody
Anti-Vascular Endothelial Cadherin antibody
Anti-Ve-Cadherin antibody
Anti-Cd Antigen Cd144 antibody
Anti-CDH5 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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