产品详情

  • 产品名称：Anti-CDC42BPA antibody (580-660) (STJ94192)

  • 产品型号：STJ94192
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CDC42BPA antibody (580-660) (STJ94192)
详情介绍：
Host: Rabbit
Applications: WB/ELISA/IHC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Serine/threonine-protein kinase MRCK alpha (580-660) is suitable for use in Western Blot, ELISA and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
IHC-p 1:50-300
ELISA 2000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CDC42BPA
Gene ID: 8476
Uniprot ID: MRCKA_HUMAN
Immunogen Region: 580-660
Specificity: MRCK Alpha Polyclonal Antibody detects endogenous levels of MRCK Alpha protein.
Immunogen: Synthesized peptide derived from the Internal region of human MRCK Alpha. AA range: 580-660
Tissue Specificity Abundant in the heart, brain, skeletal muscle, kidney, and pancreas, with little or no expression in the lung and liver.
Post Translational Modifications Proteolytically cleaved by caspases upon apoptosis induction. The cleavage at Asp-478 by CASP3 increases its kinase activity (in vitro).
Function Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates: PPP1R12A, LIMK1 and LIMK2. May play a role in TFRC-mediated iron uptake. In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodsium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodsial F-actin regulation. Triggers the formation of an extrusion apical actin ring required for epithelial extrusion of apoptotic cells.
Protein Name Serine/Threonine-Protein Kinase Mrck Alpha
Cdc42-Binding Protein Kinase Alpha
Dmpk-Like Alpha
Myotonic Dystrophy Kinase-Related Cdc42-Binding Kinase Alpha
Mrck Alpha
Myotonic Dystrophy Protein Kinase-Like Alpha
Database Links Reactome: R-HSA-9013148
Reactome: R-HSA-9013149
Reactome: R-HSA-9013406
Reactome: R-HSA-9013409
Cellular Localisation Cytoplasm
Cell Projection
Lamellipodsium
Displays A Dispersed Punctate Distribution And Concentrates Along The Cell Periphery
Especially At The Leading Edge And Cell-Cell Junction
This Concentration Is Ph-Domain Dependent
Localizes In The Lamellipodsium In A Fam89b/Lrap25-Dependent Manner
Alternative Antibody Names Anti-Serine/Threonine-Protein Kinase Mrck Alpha antibody
Anti-Cdc42-Binding Protein Kinase Alpha antibody
Anti-Dmpk-Like Alpha antibody
Anti-Myotonic Dystrophy Kinase-Related Cdc42-Binding Kinase Alpha antibody
Anti-Mrck Alpha antibody
Anti-Myotonic Dystrophy Protein Kinase-Like Alpha antibody
Anti-CDC42BPA antibody
Anti-KIAA0451 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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