产品详情

  • 产品名称：Anti-CD8A antibody [RAVB3] {FITC} (STJ97937)

  • 产品型号：STJ97937
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CD8A antibody [RAVB3] {FITC} (STJ97937)
详情介绍：
Host: Mouse
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-T-cell surface glycoprotein CD8 alpha chain is suitable for use in ELISA research applications.
Clonality: Monoclonal
Clone ID: RAVB3
Conjugation: FITC
Isotype: IgG1
Formulation: Liquid in PBS containing 0.03% Sodium Azide.
Purification: Affinity purification
Concentration: 1 mg/mL
Dilution Range: IF 1:250-1:2000
FCM 1:250-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CD8A
Gene ID: 925
Uniprot ID: CD8A_HUMAN
Specificity: CD8 Monoclonal Antibody-FITC labled detects endogenous levels of CD8 protein.
Immunogen: Purified recombinant fragment of human CD8 expressed in E. Coli.
Post Translational Modifications Palmitoylated, but association with CD8B seems to be more important for the enrichment of CD8A in lipid rafts. O-glycosylated. Phosphorylated in cytotoxic T-lymphocytes (CTLs) following activation.
Function Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.
Protein Name T-Cell Surface Glycoprotein Cd8 Alpha Chain
T-Lymphocyte Differentiation Antigen T8/Leu-2
Cd Antigen Cd8a
Database Links Reactome: R-HSA-198933
Cellular Localisation Isoform 1: Cell Membrane
Single-Pass Type I Membrane Protein
Cd8a Localizes To Lipid Rafts Only When Associated With Its Partner Cd8b
Isoform 2: Secreted
Alternative Antibody Names Anti-T-Cell Surface Glycoprotein Cd8 Alpha Chain antibody
Anti-T-Lymphocyte Differentiation Antigen T8/Leu-2 antibody
Anti-Cd Antigen Cd8a antibody
Anti-CD8A antibody
Anti-MAL antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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