产品详情

  • 产品名称：Human PIK3Cd (Phosphoinositide-3-Kinase Catalytic Delta Polypeptide) Sandwich ELISA Kit Ready-To-Use (STJE0017860)

  • 产品型号：STJE0017860
  • 产品厂商：ST john's laboratory
  • 产品文档：
你添加了1件商品 查看购物车
简单介绍：
Human PIK3Cd (Phosphoinositide-3-Kinase Catalytic Delta Polypeptide) Sandwich ELISA Kit Ready-To-Use (STJE0017860)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.086ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This PIK3Cd Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: PIK3CD
Gene ID: 5293
Uniprot ID: PK3CD_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity In humans, the highest levels of expression are seen in peripheral blood mononuclear cells, spleen, and thymus, and low levels of expression in testes, uterus, colon, and small intestine but not in other tissues examined including prostate, heart, brain, and liver. Isoform 2 is expressed in normal thymus, lung and spleen tissues, and is detected at low levels in normal lysates from colon and ovarian biopsies, at elevated levels in lysates from colorectal tumors and is abundantly expressed in some ovarian tumors (at protein level). Both isoform 1 and isoform 2 are widely expressed. Isoform 1 is expressed predominantly in leukocytes.
Post Translational Modifications Autophosphorylation on Ser-1039 results in the almost complete inactivation of the lipid kinase activity.
Function Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol (PI) and its phosphorylated derivatives at position 3 of the inositol ring to produce 3-phosphoinositides. Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Mediates immune responses. Plays a role in B-cell development, proliferation, migration, and function. Required for B-cell receptor (BCR) signaling. Mediates B-cell proliferation response to anti-IgM, anti-CD40 and IL4 stimulation. Promotes cytokine production in response to TLR4 and TLR9. Required for antibody class switch mediated by TLR9. Involved in the antigen presentation function of B-cells. Involved in B-cell chemotaxis in response to CXCL13 and sphingosine 1-phosphate (S1P). Required for proliferation, signaling and cytokine production of naive, effector and memory T-cells. Required for T-cell receptor (TCR) signaling. Mediates TCR signaling events at the immune synapse. Activation by TCR leads to antigen-dependent memory T-cell migration and retention to antigenic tissues. Together with PIK3CG participates in T-cell development. Contributes to T-helper cell expansion and differentiation. Required for T-cell migration mediated by homing receptors SELL/CD62L, CCR7 and S1PR1 and antigen dependent recruitment of T-cells. Together with PIK3CG is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in NK cell receptor activation. Plays a role in NK cell maturation and cytokine production. Together with PIK3CG is involved in neutrophil chemotaxis and extravasation. Together with PIK3CG participates in neutrophil respiratory burst. Plays important roles in mast-cell development and mast cell mediated allergic response. Involved in stem cell factor (SCF)-mediated proliferation, adhesion and migration. Required for allergen-IgE-induced degranulation and cytokine release. The lipid kinase activity is required for its biological function. Isoform 2 may be involved in stabilizing total RAS levels, resulting in increased ERK phosphorylation and increased PI3K activity.
Protein Name Phosphatidylinositol 4 -5-Bisphosphate 3-Kinase Catalytic Subunit Delta Isoform
Pi3-Kinase Subunit Delta
Pi3k-Delta
Pi3kdelta
Ptdins-3-Kinase Subunit Delta
Phosphatidylinositol 4 -5-Bisphosphate 3-Kinase 110 Kda Catalytic Subunit Delta
Ptdins-3-Kinase Subunit P110-Delta
P110delta
Database Links Reactome: R-HSA-1257604
Reactome: R-HSA-1660499
Reactome: R-HSA-2219530
Reactome: R-HSA-512988
Reactome: R-HSA-6811558
Reactome: R-HSA-8853659
Reactome: R-HSA-9027276
Reactome: R-HSA-912526
Reactome: R-HSA-912631
Reactome: R-HSA-983695
Cellular Localisation Cytoplasm
Alternative ELISA Names Phosphatidylinositol 4 -5-Bisphosphate 3-Kinase Catalytic Subunit Delta Isoform ELISA kit
Pi3-Kinase Subunit Delta ELISA kit
Pi3k-Delta ELISA kit
Pi3kdelta ELISA kit
Ptdins-3-Kinase Subunit Delta ELISA kit
Phosphatidylinositol 4 -5-Bisphosphate 3-Kinase 110 Kda Catalytic Subunit Delta ELISA kit
Ptdins-3-Kinase Subunit P110-Delta ELISA kit
P110delta ELISA kit
PIK3CD ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
姓名：
电话：
您的需求：
 
网站地图