产品详情

  • 产品名称：Anti-C3d antibody (STJ16101317)

  • 产品型号：STJ16101317
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-C3d antibody (STJ16101317)
详情介绍：
Host: Rabbit
Applications: IHC-P
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-C3d is suitable for use in Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Formulation: Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% sodium="" azide<="" td="">
Purification: Affinity purified
Dilution Range: IHC-P 1:100-1:500
Storage Instruction: Store at 2-8°C upon receipt.
Background Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. C3d deposition in the renal transplant PTCs (peritubular capillaries) is indicative of AR (acute rejection) with subsequent high probability of graft loss. Anti-C3d, combined with anti-C4d, can be utilized as a tool for diagnosis of AR and warrant prompt and aggressive anti-rejection treatment. In another study, Pfaltz et al. have shown that anti-C3d labeled the epidermal basement membrane in 97% (31/32) cases of bullous pemphigoid (BP) , with none of the normal controls demonstrating such findings. In the same study 27% (3/11) cases of pemphigus vulgaris (PV) demonstrated intercellular C3d deposition. Therefore, C3d immunohistochemistry is a helpful adjunct in the diagnosis of BP (and perhaps PV) , especially in the cases in which only formalin-fixed, paraffin embedded tissue is available for analysis.

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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