产品详情

  • 产品名称：Anti-C2CD2L antibody (STJA0009539)

  • 产品型号：STJA0009539
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-C2CD2L antibody (STJA0009539)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospholipid transfer protein C2CD2L is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: C2CD2L
Gene ID: 9854
Uniprot ID: C2C2L_HUMAN
Specificity: This antibody detects endogenous levels of TMEM24 at Human, Mouse
Immunogen: Synthesized peptide derived from human TMEM24
Function Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane. It thereby maintains the pool of cell membrane phosphoinositides, which are degraded during phospholipase C (PLC) signaling. Plays a key role in the coordination of Ca(2+) and phosphoinositide signaling: localizes to sites of contact between the endoplasmic reticulum and the cell membrane, where it tethers the two bilayers. In response to elevation of cytosolic Ca(2+), it is phosphorylated at its C-terminus and dissociates from the cell membrane, abolishing phosphatidylinositol transport to the cell membrane. Positively regulates insulin secretion in response to glucose: phosphatidylinositol transfer to the cell membrane allows replenishment of PI(4,5)P2 pools and calcium channel opening, priming a new population of insulin granules.
Protein Name Phospholipid Transfer Protein C2cd2l
C2 Domain-Containing Protein 2-Like
C2cd2-Like
Transmembrane Protein 24
Cellular Localisation Endoplasmic Reticulum Membrane
Single-Pass Membrane Protein
Cell Membrane
Peripheral Membrane Protein
Localizes To Sites Of Contact Between The Endoplasmic Reticulum And The Cell Membrane
Embedded Into The Endoplasmic Reticulum Membrane Via Its N-Terminal Transmembrane Domain And Associates With Cell Membrane Via Its C-Terminus
In Response To Elevation Of Cytosolic Ca(2+)
It Is Phosphorylated At Its C-Terminus And Dissociates From The Cell Membrane And Localizes To The Reticular Endoplasmic Reticulum
Reassociates With Cell Membrane Upon Dephosphorylation
Alternative Antibody Names Anti-Phospholipid Transfer Protein C2cd2l antibody
Anti-C2 Domain-Containing Protein 2-Like antibody
Anti-C2cd2-Like antibody
Anti-Transmembrane Protein 24 antibody
Anti-C2CD2L antibody
Anti-KIAA0285 antibody
Anti-TMEM24 antibody
Anti-DLNB23 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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