产品详情

  • 产品名称：Anti-CD86 antibody [BU63] {PE/Cyanine5.5} (STJA0001275)

  • 产品型号：STJA0001275
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CD86 antibody [BU63] {PE/Cyanine5.5} (STJA0001275)
详情介绍：
Host: Mouse
Applications: FC
Reactivity: Human
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-T-lymphocyte activation antigen CD86 is suitable for use in Flow Cytometry research applications.
Clonality: Monoclonal
Clone ID: BU63
Conjugation: PE/Cyanine5.5
Isotype: IgG1k
Formulation: PBS with 0.05% Proclin300, 1% BSA
Storage Instruction: Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product.
Gene Symbol: CD86
Gene ID: 942
Uniprot ID: CD86_HUMAN
Tissue Specificity Expressed by activated B-lymphocytes and monocytes.
Post Translational Modifications Polyubiquitinated.which is promoted by MARCH8 and results in endocytosis and lysosomal degradation.
Function Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Also involved in the regulation of B cells function, plays a role in regulating the level of IgG(1) produced. Upon CD40 engagement, activates NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation. Isoform 2: Interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. (Microbial infection) Acts as a receptor for adenovirus subgroup B.
Protein Name T-Lymphocyte Activation Antigen Cd86
Activation B7-2 Antigen
B70
Bu63
Ctla-4 Counter-Receptor B7.2
Fun-1
Cd Antigen Cd86
Database Links Reactome: R-HSA-1257604
Reactome: R-HSA-2219530
Reactome: R-HSA-389356
Reactome: R-HSA-389357
Reactome: R-HSA-389359
Reactome: R-HSA-389513
Reactome: R-HSA-6783783
Reactome: R-HSA-6811558
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-T-Lymphocyte Activation Antigen Cd86 antibody
Anti-Activation B7-2 Antigen antibody
Anti-B70 antibody
Anti-Bu63 antibody
Anti-Ctla-4 Counter-Receptor B7.2 antibody
Anti-Fun-1 antibody
Anti-Cd Antigen Cd86 antibody
Anti-CD86 antibody
Anti-CD28LG2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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