产品详情

  • 产品名称：Anti-CD63 antibody (Extracellular region) [M040] (STJA0005328)

  • 产品型号：STJA0005328-100
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CD63 antibody (Extracellular region) [M040] (STJA0005328)
详情介绍：
Host: Mouse
Applications: WB/ICC
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-CD63 (Extracellular region) is suitable for use in Western Blot and Immunocytochemistry research applications.
Clonality: Monoclonal
Clone ID: M040
Conjugation: Unconjugated
Isotype: IgG2a
Formulation: PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol
Purification: Protein G Purified
Dilution Range: WB 1:100
IHC
ICC 1:500
IP
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CD63
Gene ID: 967
Uniprot ID: CD63_HUMAN
Immunogen Region: Extracellular region
Specificity: Clone M040 mouse monoclonal antibody has high reactivity to CD63 at the plasma membrane in immunocytochemical assays, and weakly detects a 30-60 kDa* protein on SDS-PAGE Native" immunoblots of human A431, MeWo, and A549 cells. The antibody does not d
Immunogen: Clone (M040) was generated from a proprietary antigen related to the native human CD63 expressed in MeWo melanoma cell line.
Tissue Specificity Detected in platelets (at protein level). Dysplastic nevi, radial growth phase primary melanomas, hematopoietic cells, tissue macrophages.
Post Translational Modifications Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro).
Function Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.
Protein Name Cd63 Antigen
Granulophysin
Lysosomal-Associated Membrane Protein 3
Lamp-3
Lysosome Integral Membrane Protein 1
Limp1
Melanoma-Associated Antigen Me491
Oma81h
Ocular Melanoma-Associated Antigen
Tetraspanin-30
Tspan-30
Cd Antigen Cd63
Database Links Reactome: R-HSA-114608
Reactome: R-HSA-6798695
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Lysosome Membrane
Late Endosome Membrane
Endosome
Multivesicular Body
Melanosome
Secreted
Extracellular Exosome
Cell Surface
Also Found In Weibel-Palade Bodies Of Endothelial Cells
Located In Platelet Dense Granules
Detected In A Subset Of Pre-Melanosomes
Detected On Intralumenal Vesicles (Ilvs) Within Multivesicular Bodies
Alternative Antibody Names Anti-Cd63 Antigen antibody
Anti-Granulophysin antibody
Anti-Lysosomal-Associated Membrane Protein 3 antibody
Anti-Lamp-3 antibody
Anti-Lysosome Integral Membrane Protein 1 antibody
Anti-Limp1 antibody
Anti-Melanoma-Associated Antigen Me491 antibody
Anti-Oma81h antibody
Anti-Ocular Melanoma-Associated Antigen antibody
Anti-Tetraspanin-30 antibody
Anti-Tspan-30 antibody
Anti-Cd Antigen Cd63 antibody
Anti-CD63 antibody
Anti-MLA1 antibody
Anti-TSPAN30 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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