产品详情

  • 产品名称：Human PAR1 (Protease Activated Receptor 1) Sandwich ELISA Kit Ready-To-Use (STJE0017661)

  • 产品型号：STJE0017661
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human PAR1 (Protease Activated Receptor 1) Sandwich ELISA Kit Ready-To-Use (STJE0017661)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.059ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This PAR1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: F2R
Gene ID: 2149
Uniprot ID: PAR1_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Platelets and vascular endothelial cells.
Post Translational Modifications Proteolytic cleavage by thrombin generates a new N-terminus that functions as a tethered ligand. Also proteolytically cleaved by cathepsin CTSG. Cleavage at 41-Arg-|-Ser-42 by CTSG results in receptor activation while cleavage at 55-Phe-|-Trp-56 results in inhibition of receptor activation. Phosphorylated in the C-terminal tail.probably mediating desensitization prior to the uncoupling and internalization of the receptor.
Function High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.
Protein Name Proteinase-Activated Receptor 1
Par-1
Coagulation Factor Ii Receptor
Thrombin Receptor
Database Links Reactome: R-HSA-140875
Reactome: R-HSA-375276
Reactome: R-HSA-416476
Reactome: R-HSA-456926
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative ELISA Names Proteinase-Activated Receptor 1 ELISA kit
Par-1 ELISA kit
Coagulation Factor Ii Receptor ELISA kit
Thrombin Receptor ELISA kit
F2R ELISA kit
CF2R ELISA kit
PAR1 ELISA kit
TR ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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