产品详情

  • 产品名称：Human OPTN (Optineurin) Sandwich ELISA Kit Ready-To-Use (STJE0017590)

  • 产品型号：STJE0017590
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human OPTN (Optineurin) Sandwich ELISA Kit Ready-To-Use (STJE0017590)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 34.56pg/mL
Detection Limit: 78.1-5000pg/mL
Short Description: This OPTN Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: OPTN
Gene ID: 10133
Uniprot ID: OPTN_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity Present in aqueous humor of the eye (at protein level). Expressed in the trabecular meshwork (at protein level). Expressed in nonpigmented ciliary epithelium (at protein level). Expressed at high levels in skeletal muscle, also detected in heart, brain, pancreas, kidney, placenta and liver. Expressed in dermal fibroblasts (at protein level).
Post Translational Modifications Phosphorylated by TBK1, leading to restrict bacterial proliferation in case of infection. Phosphorylation is induced by phorbol esters and decreases its half-time.
Function Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Plays a role in the activation of innate immune response during viral infection. Mechanistically, recruits TBK1 at the Golgi apparatus, promoting its trans-phosphorylation after RLR or TLR3 stimulation. In turn, activated TBK1 phosphorylates its downstream partner IRF3 to produce IFN-beta/IFNB1. Plays a neuroprotective role in the eye and optic nerve. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). Mediates the interaction of Rab8 with the probable GTPase-activating protein TBC1D17 during Rab8-mediated endocytic trafficking, such as that of transferrin receptor (TFRC/TfR).regulates Rab8 recruitment to tubules emanating from the endocytic recycling compartment. Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family.targets ubiquitin-coated bacteria (xenophagy), such as cytoplasmic Salmonella enterica, and appears to function in the same pathway as SQSTM1 and CALCOCO2/NDP52. (Microbial infection) May constitute a cellular target for various viruses, such as adenovirus E3 14.7 or Bluetongue virus, to inhibit innate immune response. During RNA virus infection, such as that of Sendai virus, negatively regulates the induction of IFNB1.
Protein Name Optineurin
E3-14.7k-Interacting Protein
Fip-2
Huntingtin Yeast Partner L
Huntingtin-Interacting Protein 7
Hip-7
Huntingtin-Interacting Protein L
Nemo-Related Protein
Optic Neuropathy-Inducing Protein
Transcription Factor Iiia-Interacting Protein
Tfiiia-Intp
Database Links Reactome: R-HSA-2565942
Reactome: R-HSA-5357786
Reactome: R-HSA-5357905
Reactome: R-HSA-5357956
Reactome: R-HSA-8854214
Cellular Localisation Cytoplasm
Perinuclear Region
Golgi Apparatus
Trans-Golgi Network
Cytoplasmic Vesicle
Autophagosome
Recycling Endosome
Found In The Perinuclear Region And Associates With The Golgi Apparatus
Colocalizes With Myo6 And Rab8 At The Golgi Complex And In Vesicular Structures Close To The Plasma Membrane
Localizes To Lc3-Positive Cytoplasmic Vesicles Upon Induction Of Autophagy
Alternative ELISA Names Optineurin ELISA kit
E3-14.7k-Interacting Protein ELISA kit
Fip-2 ELISA kit
Huntingtin Yeast Partner L ELISA kit
Huntingtin-Interacting Protein 7 ELISA kit
Hip-7 ELISA kit
Huntingtin-Interacting Protein L ELISA kit
Nemo-Related Protein ELISA kit
Optic Neuropathy-Inducing Protein ELISA kit
Transcription Factor Iiia-Interacting Protein ELISA kit
Tfiiia-Intp ELISA kit
OPTN ELISA kit
FIP2 ELISA kit
GLC1E ELISA kit
HIP7 ELISA kit
HYPL ELISA kit
NRP ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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