产品详情

  • 产品名称：Anti-CD45RO/PTPRC antibody [UCHL1] {AF647} (STJA0001844)

  • 产品型号：STJA0001844
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CD45RO/PTPRC antibody [UCHL1] {AF647} (STJA0001844)
详情介绍：
Host: Mouse
Applications: FC
Reactivity: Human
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Receptor-type tyrosine-protein phosphatase C is suitable for use in Flow Cytometry research applications.
Clonality: Monoclonal
Clone ID: UCHL1
Conjugation: AF647
Isotype: IgG2ak
Formulation: PBS with 0.05% Proclin300, 1% BSA
Storage Instruction: Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product.
Gene Symbol: PTPRC
Gene ID: 5788
Uniprot ID: PTPRC_HUMAN
Tissue Specificity Isoform 1: Detected in thymocytes. Isoform 2: Detected in thymocytes. Isoform 3: Detected in thymocytes. Isoform 4: Not detected in thymocytes. Isoform 5: Detected in thymocytes. Isoform 6: Not detected in thymocytes. Isoform 7: Detected in thymocytes. Isoform 8: Not detected in thymocytes.
Post Translational Modifications Heavily N- and O-glycosylated.
Function Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity. (Microbial infection) Acts as a receptor for human cytomegalovirus protein UL11 and mediates binding of UL11 to T-cells, leading to reduced induction of tyrosine phosphorylation of multiple signaling proteins upon T-cell receptor stimulation and impaired T-cell proliferation.
Protein Name Receptor-Type Tyrosine-Protein Phosphatase C
Leukocyte Common Antigen
L-Ca
T200
Cd Antigen Cd45
Database Links Reactome: R-HSA-202427
Reactome: R-HSA-416700
Reactome: R-HSA-6798695
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Membrane Raft
Colocalized With Dpp4 In Membrane Rafts
Alternative Antibody Names Anti-Receptor-Type Tyrosine-Protein Phosphatase C antibody
Anti-Leukocyte Common Antigen antibody
Anti-L-Ca antibody
Anti-T200 antibody
Anti-Cd Antigen Cd45 antibody
Anti-PTPRC antibody
Anti-CD45 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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