产品详情

  • 产品名称：Human OAS3 (2 NA, 5 Oligoadenylate Synthetase 3) Sandwich ELISA Kit (STJE0011153)

  • 产品型号：STJE0011153
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human OAS3 (2 NA, 5 Oligoadenylate Synthetase 3) Sandwich ELISA Kit (STJE0011153)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 2.27ng/mL
Detection Limit: 6.25-400ng/mL
Short Description: This OAS3 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: OAS3
Gene ID: 4940
Uniprot ID: OAS3_HUMAN
Sample Type: serum, plasma, tissue homogenates or other biological fluids.
Tissue Specificity Present at high level in placenta trophoblast.
Post Translational Modifications
Function Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus (SFV).
Protein Name 2'-5'-Oligoadenylate Synthase 3
(2-5'Oligo(A Synthase 3
2-5a Synthase 3
P100 Oas
P100oas
Database Links Reactome: R-HSA-877300
Reactome: R-HSA-8983711
Reactome: R-HSA-909733
Cellular Localisation Cytoplasm
Nucleus
Alternative ELISA Names 2'-5'-Oligoadenylate Synthase 3 ELISA kit
(2-5'Oligo(A Synthase 3 ELISA kit
2-5a Synthase 3 ELISA kit
P100 Oas ELISA kit
P100oas ELISA kit
OAS3 ELISA kit
P ELISA kit
OKcl.4 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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