产品详情

  • 产品名称：Human NPC2 (Niemann Pick Disease Type C2) Sandwich ELISA Kit Ready-To-Use (STJE0017414)

  • 产品型号：STJE0017414
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human NPC2 (Niemann Pick Disease Type C2) Sandwich ELISA Kit Ready-To-Use (STJE0017414)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.31ng/mL
Detection Limit: 0.781-50ng/mL
Short Description: This NPC2 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: NPC2
Gene ID: 10577
Uniprot ID: NPC2_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: serum, plasma, tissue homogenates or other biological fluids.
Tissue Specificity Detected in gallbladder bile. Detected in fibroblasts, kidney, liver, spleen, small intestine, placenta and testis (at protein level). Epididymis.
Post Translational Modifications
Function Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes. NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol. The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport.
Protein Name Npc Intracellular Cholesterol Transporter 2
Epididymal Secretory Protein E1
Human Epididymis-Specific Protein 1
He1
Niemann-Pick Disease Type C2 Protein
Database Links Reactome: R-HSA-6798695
Reactome: R-HSA-8964038
Cellular Localisation Secreted
Endoplasmic Reticulum
Lysosome
Interaction With Cell-Surface M6pr Mediates Endocytosis And Targeting To Lysosomes
Alternative ELISA Names Npc Intracellular Cholesterol Transporter 2 ELISA kit
Epididymal Secretory Protein E1 ELISA kit
Human Epididymis-Specific Protein 1 ELISA kit
He1 ELISA kit
Niemann-Pick Disease Type C2 Protein ELISA kit
NPC2 ELISA kit
HE1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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