产品详情

  • 产品名称：Anti-CD196/CCR6 antibody [G034E3] {PE} (STJA0001913)

  • 产品型号：STJA0001913
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CD196/CCR6 antibody [G034E3] {PE} (STJA0001913)
详情介绍：
Host: Mouse
Applications: FC
Reactivity: Human
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-C-C chemokine receptor type 6 is suitable for use in Flow Cytometry research applications.
Clonality: Monoclonal
Clone ID: G034E3
Conjugation: PE
Isotype: IgG2bk
Formulation: PBS with 0.05% Proclin300, 1% BSA
Storage Instruction: Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product.
Gene Symbol: CCR6
Gene ID: 1235
Uniprot ID: CCR6_HUMAN
Tissue Specificity Sperm. Mainly localized in the tail and in the postacrosomal region but is also found in the midpsiece and basal region in a small percentage of sperm cells. Reduced levels found in the sperms of asthenozoospermia and leukocytospermia patients (at protein level). Spleen, lymph nodes, appendix, and fetal liver. Expressed in lymphocytes, T-cells and B-cells but not in natural killer cells, monocytes or granulocytes.
Function Receptor for the C-C type chemokine CCL20. Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels. Although CCL20 is its major ligand it can also act as a receptor for non-chemokine ligands such as beta-defensins. Binds to defensin DEFB1 leading to increase in intracellular calcium ions and cAMP levels. Its binding to DEFB1 is essential for the function of DEFB1 in regulating sperm motility and bactericidal activity. Binds to defensins DEFB4 and DEFB4A/B and mediates their chemotactic effects. The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/ memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases. CCR6-mediated signals are essential for immune responses to microbes in the intestinal mucosa and in the modulation of inflammatory responses initiated by tissue insult and trauma. CCR6 is essential for the recruitment of both the pro-inflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for the normal migration of Th17 cells in Peyers-patches and other related tissue sites of the intestine and plays a role in regulating effector T-cell balance and distribution in inflamed intestine. Plays an important role in the coordination of early thymocyte precursor migration events important for normal subsequent thymocyte precursor development, but is not required for the formation of normal thymic natural regulatory T-cells (nTregs). Required for optimal differentiation of DN2 and DN3 thymocyte precursors. Essential for B-cell localization in the subepithelial dome of Peyers-patches and for efficient B-cell isotype switching to IgA in the Peyers-patches. Essential for appropriate anatomical distribution of memory B-cells in the spleen and for the secondary recall response of memory B-cells. Positively regulates sperm motility and chemotaxis via its binding to CCL20.
Protein Name C-C Chemokine Receptor Type 6
C-C Ckr-6
Cc-Ckr-6
Ccr-6
Chemokine Receptor-Like 3
Ckr-L3
Dry6
G-Protein Coupled Receptor 29
Gpr-Cy4
Gprcy4
Larc Receptor
Cd Antigen Cd196
Database Links Reactome: R-HSA-1461957
Reactome: R-HSA-380108
Reactome: R-HSA-418594
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Cell Surface
Alternative Antibody Names Anti-C-C Chemokine Receptor Type 6 antibody
Anti-C-C Ckr-6 antibody
Anti-Cc-Ckr-6 antibody
Anti-Ccr-6 antibody
Anti-Chemokine Receptor-Like 3 antibody
Anti-Ckr-L3 antibody
Anti-Dry6 antibody
Anti-G-Protein Coupled Receptor 29 antibody
Anti-Gpr-Cy4 antibody
Anti-Gprcy4 antibody
Anti-Larc Receptor antibody
Anti-Cd Antigen Cd196 antibody
Anti-CCR6 antibody
Anti-CKRL3 antibody
Anti-CMKBR6 antibody
Anti-GPR29 antibody
Anti-STRL22 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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