产品详情

  • 产品名称：Human LRP1 (Low Density Lipoprotein Receptor Related Protein 1) Sandwich ELISA Kit (STJE0010417)

  • 产品型号：STJE0010417
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human LRP1 (Low Density Lipoprotein Receptor Related Protein 1) Sandwich ELISA Kit (STJE0010417)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.061ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This LRP1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: LRP1
Gene ID: 4035
Uniprot ID: LRP1_HUMAN
Sample Type: serum, plasma or other biological fluids.
Tissue Specificity Most abundant in liver, brain and lung.
Post Translational Modifications Cleaved into a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515) that remains non-covalently associated. Gamma-secretase-dependent cleavage of LRP-85 releases the intracellular domain from the membrane. The N-terminus is blocked. Phosphorylated on serine and threonine residues. Phosphorylated on tyrosine residues upon stimulation with PDGF. Tyrosine phosphorylation promotes interaction with SHC1.
Function Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an LRPAP1 alpha-2-macroglobulin receptor. Acts as TAU/MAPT receptor and controls the endocytosis of TAU/MAPT as well as its subsequent spread. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission. (Microbial infection) Functions as a receptor for Pseudomonas aeruginosa exotoxin A.
Protein Name Prolow-Density Lipoprotein Receptor-Related Protein 1
Lrp-1
Alpha-2-Macroglobulin Receptor
A2mr
Apolipoprotein E Receptor
Apoer
Cd Antigen Cd91 Cleaved Into - Low-Density Lipoprotein Receptor-Related Protein 1 85 Kda Subunit
Lrp-85 - Low-Density Lipoprotein Receptor-Related Protein 1 515 Kda Subunit
Lrp-515 - Low-Density Lipoprotein Receptor-Related Protein 1 Intracellular Domain
Lrpicd
Database Links Reactome: R-HSA-2168880
Reactome: R-HSA-975634
Cellular Localisation Low-Density Lipoprotein Receptor-Related Protein 1 85 Kda Subunit: Cell Membrane
Single-Pass Type I Membrane Protein
Membrane
Coated Pit
Low-Density Lipoprotein Receptor-Related Protein 1 515 Kda Subunit: Cell Membrane
Peripheral Membrane Protein
Extracellular Side
Low-Density Lipoprotein Receptor-Related Protein 1 Intracellular Domain: Cytoplasm
Nucleus
After Cleavage
The Intracellular Domain (Lrpicd) Is Detected Both In The Cytoplasm And In The Nucleus
Golgi Outpost
Cytoplasm
Cytoskeleton
Microtubule Organizing Center
Localizes To The Postsynaptic Golgi Apparatus Region
Also Named Golgi Outpost
Which Shapes Dendrite Morphology By Functioning As Sites Of Acentrosomal Microtubule Nucleation
Alternative ELISA Names Prolow-Density Lipoprotein Receptor-Related Protein 1 ELISA kit
Lrp-1 ELISA kit
Alpha-2-Macroglobulin Receptor ELISA kit
A2mr ELISA kit
Apolipoprotein E Receptor ELISA kit
Apoer ELISA kit
Cd Antigen Cd91 Cleaved Into - Low-Density Lipoprotein Receptor-Related Protein 1 85 Kda Subunit ELISA kit
Lrp-85 - Low-Density Lipoprotein Receptor-Related Protein 1 515 Kda Subunit ELISA kit
Lrp-515 - Low-Density Lipoprotein Receptor-Related Protein 1 Intracellular Domain ELISA kit
Lrpicd ELISA kit
LRP1 ELISA kit
A2MR ELISA kit
APR ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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