产品详情

  • 产品名称：Human LEI (Leukocyte Elastase Inhibitor) Sandwich ELISA Kit (STJE0010308)

  • 产品型号：STJE0010308
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human LEI (Leukocyte Elastase Inhibitor) Sandwich ELISA Kit (STJE0010308)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.117ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This LEI Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: SERPINB1
Gene ID: 1992
Uniprot ID: ILEU_HUMAN
Sample Type: serum, plasma, tissue homogenates or other biological fluids.
Tissue Specificity In human bone marrow, present in all CD45+ populations. Expression levels are highest in the neutrophil lineage, intermediate in monocytic, and lowest in lymphocytic lineage. Within the neutrophil lineage, expression is highest in promyelocytes.
Post Translational Modifications
Function Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis. Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection. These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3. Acts also as a potent intracellular inhibitor of GZMH by directly blocking its proteolytic activity. During inflammation, limits the activity of inflammatory caspases CASP1, CASP4 and CASP5 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation. When secreted, promotes the proliferation of beta-cells via its protease inhibitory function.
Protein Name Leukocyte Elastase Inhibitor
Lei
Monocyte/Neutrophil Elastase Inhibitor
Ei
M/Nei
Peptidase Inhibitor 2
Pi-2
Serpin B1
Database Links Reactome: R-HSA-6798695
Cellular Localisation Secreted
Cytoplasm
Cytolytic Granule
Early Endosome
Alternative ELISA Names Leukocyte Elastase Inhibitor ELISA kit
Lei ELISA kit
Monocyte/Neutrophil Elastase Inhibitor ELISA kit
Ei ELISA kit
M/Nei ELISA kit
Peptidase Inhibitor 2 ELISA kit
Pi-2 ELISA kit
Serpin B1 ELISA kit
SERPINB1 ELISA kit
ELANH2 ELISA kit
MNEI ELISA kit
PI2 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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