产品详情

  • 产品名称：Anti-CD11a/ITGAL antibody [R7-1] (STJA0002186)

  • 产品型号：STJA0002186
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CD11a/ITGAL antibody [R7-1] (STJA0002186)
详情介绍：
Host: Mouse
Applications: FA/FC
Reactivity: Human
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Integrin alpha-L is suitable for use in FA and Flow Cytometry research applications.
Clonality: Monoclonal
Clone ID: R7-1
Conjugation: Unconjugated
Isotype: IgG1k
Formulation: 0.2 µm filtered in PBS, pH7.2. Azide Free (AF) /Low Endotoxin (LE) : Contains no stabilizers or preservatives. Endotoxin level is < 2 EU/mg as determined by LAL gel clotting assay.
Concentration: 0.5 mg/mL
Storage Instruction: Store at 2-8°C. Do not freeze this product.
Gene Symbol: ITGAL
Gene ID: 3683
Uniprot ID: ITAL_HUMAN
Tissue Specificity Leukocytes.
Post Translational Modifications In resting T-cells, up to 40% of surface ITGAL is constitutively phosphorylated. Phosphorylation causes conformational changes needed for ligand binding and is necessary for activation by some physiological agents.
Function Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is a receptor for F11R. Integrin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15.the interaction is mediated by ITGAL. Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis. Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages.
Protein Name Integrin Alpha-L
Cd11 Antigen-Like Family Member A
Leukocyte Adhesion Glycoprotein Lfa-1 Alpha Chain
Lfa-1a
Leukocyte Function-Associated Molecule 1 Alpha Chain
Cd Antigen Cd11a
Database Links Reactome: R-HSA-198933
Reactome: R-HSA-202733
Reactome: R-HSA-216083
Reactome: R-HSA-6798695
Reactome: R-HSA-8949275
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Integrin Alpha-L antibody
Anti-Cd11 Antigen-Like Family Member A antibody
Anti-Leukocyte Adhesion Glycoprotein Lfa-1 Alpha Chain antibody
Anti-Lfa-1a antibody
Anti-Leukocyte Function-Associated Molecule 1 Alpha Chain antibody
Anti-Cd Antigen Cd11a antibody
Anti-ITGAL antibody
Anti-CD11A antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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