产品详情

  • 产品名称：Anti-CCR5 antibody (246-345) (STJ11103247)

  • 产品型号：STJ11103247
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CCR5 antibody (246-345) (STJ11103247)
详情介绍：
Host: Rabbit
Applications: WB/IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CCR5 (246-345) is suitable for use in Western Blot and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CCR5
Gene ID: 1234
Uniprot ID: CCR5_HUMAN
Immunogen Region: 246-345
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 246-345 of human CCR5 (NP_000570.1).
Immunogen Sequence: LFWAPYNIVLLLNTFQEFFG LNNCSSSNRLDQAMQVTETL GMTHCCINPIIYAFVGEKFR NYLLVFFQKHIAKRFCKCCS IFQQEAPERASSVYTRSTGE
Tissue Specificity Highly expressed in spleen, thymus, in the myeloid cell line THP-1, in the promyeloblastic cell line KG-1a and on CD4+ and CD8+ T-cells. Medium levels in peripheral blood leukocytes and in small intestine. Low levels in ovary and lung.
Post Translational Modifications Sulfated on at least 2 of the N-terminal tyrosines. Sulfation contributes to the efficiency of HIV-1 entry and is required for efficient binding of the chemokines, CCL3 and CCL4. O-glycosylated, but not N-glycosylated. Ser-6 appears to be the major site even if Ser-7 may be also O-glycosylated. Also sialylated glycans present which contribute to chemokine binding. Thr-16 and Ser-17 may also be glycosylated and, if so, with small moieties such as a T-antigen. Palmitoylation in the C-terminal is important for cell surface expression, and to a lesser extent, for HIV entry. Phosphorylation on serine residues in the C-terminal is stimulated by binding CC chemokines especially by APO-RANTES.
Function Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor. (Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) of human immunodeficiency virus-1/HIV-1.
Protein Name C-C Chemokine Receptor Type 5
C-C Ckr-5
Cc-Ckr-5
Ccr-5
Ccr5
Chemr13
Hiv-1 Fusion Coreceptor
Cd Antigen Cd195
Database Links Reactome: R-HSA-173107
Reactome: R-HSA-380108
Reactome: R-HSA-418594
Reactome: R-HSA-6783783
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-C-C Chemokine Receptor Type 5 antibody
Anti-C-C Ckr-5 antibody
Anti-Cc-Ckr-5 antibody
Anti-Ccr-5 antibody
Anti-Ccr5 antibody
Anti-Chemr13 antibody
Anti-Hiv-1 Fusion Coreceptor antibody
Anti-Cd Antigen Cd195 antibody
Anti-CCR5 antibody
Anti-CMKBR5 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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