产品详情

  • 产品名称：Anti-BACE2 antibody (240-470) (STJ117064)

  • 产品型号：STJ117064
  • 产品厂商：ST john's laboratory
  • 产品文档：
你添加了1件商品 查看购物车
简单介绍：
Anti-BACE2 antibody (240-470) (STJ117064)
详情介绍：
Host: Rabbit
Applications: WB/IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-BACE2 (240-470) is suitable for use in Western Blot and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: BACE2
Gene ID: 25825
Uniprot ID: BACE2_HUMAN
Immunogen Region: 240-470
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 240-470 of human BACE2 (NP_036237.2).
Immunogen Sequence: AGSGTNGGSLVLGGIEPSLY KGDIWYTPIKEEWYYQIEIL KLEIGGQSLNLDCREYNADK AIVDSGTTLLRLPQKVFDAV VEAVARASLIPEFSDGFWTG SQLACWTNSETPWSYFPKIS IYLRDENSSRSFRITILPQL YIQPMMGAGLNYECYRFGIS PSTNALVIGATVMEGFYVIF DRAQKRVGFAASPCAEIAGA AVSEISGPFSTEDVASNCVP AQSLSEPILWI
Tissue Specificity Brain. Present in neurons within the hippocampus, frontal cortex and temporal cortex (at protein level). Expressed at low levels in most peripheral tissues and at higher levels in colon, kidney, pancreas, placenta, prostate, stomach and trachea. Expressed at low levels in the brain. Found in spinal cord, medulla oblongata, substantia nigra and locus coruleus. Expressed in the ductal epithelium of both normal and malignant prostate.
Post Translational Modifications Undergoes autoproteolytic cleavage. Glycosylated.
Function Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Involved in the proteolytic shedding of PMEL at early stages of melanosome biogenesis. Cleaves PMEL within the M-beta fragment to release the amyloidogenic PMEL luminal fragment containing M-alpha and a small portion of M-beta N-terminus. This is a prerequisite step for subsequent processing and assembly of PMEL fibrils into amyloid sheets. Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells.
Protein Name Beta-Secretase 2
Aspartic-Like Protease 56 Kda
Aspartyl Protease 1
Asp1
Asp 1
Beta-Site Amyloid Precursor Protein Cleaving Enzyme 2
Beta-Site App Cleaving Enzyme 2
Down Region Aspartic Protease
Drap
Memapsin-1
Membrane-Associated Aspartic Protease 1
Theta-Secretase
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Golgi Apparatus
Endoplasmic Reticulum
Endosome
Melanosome
Colocalizes With Pmel In Stage I And Ii Melanosomes
Alternative Antibody Names Anti-Beta-Secretase 2 antibody
Anti-Aspartic-Like Protease 56 Kda antibody
Anti-Aspartyl Protease 1 antibody
Anti-Asp1 antibody
Anti-Asp 1 antibody
Anti-Beta-Site Amyloid Precursor Protein Cleaving Enzyme 2 antibody
Anti-Beta-Site App Cleaving Enzyme 2 antibody
Anti-Down Region Aspartic Protease antibody
Anti-Drap antibody
Anti-Memapsin-1 antibody
Anti-Membrane-Associated Aspartic Protease 1 antibody
Anti-Theta-Secretase antibody
Anti-BACE2 antibody
Anti-AEPLC antibody
Anti-ALP56 antibody
Anti-ASP21 antibody
Anti-CDA13 antibody
Anti-UNQ418 antibody
Anti-PRO852 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
姓名：
电话：
您的需求：
 
网站地图