产品详情

  • 产品名称：Human IMPDH2 (Inosine 5 Monophosphate Dehydrogenase 2) Sandwich ELISA Kit (STJE0009994)

  • 产品型号：STJE0009994
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human IMPDH2 (Inosine 5 Monophosphate Dehydrogenase 2) Sandwich ELISA Kit (STJE0009994)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.27ng/mL
Detection Limit: 0.781-50ng/mL
Short Description: This IMPDH2 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: IMPDH2
Gene ID: 3615
Uniprot ID: IMDH2_HUMAN
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity IMPDH1 is the main species in normal leukocytes and IMPDH2 predominates over IMPDH1 in the tumor.
Post Translational Modifications Ubiquitinated leading to its degradation by the proteasome. The N-terminus is blocked. Acetylated by CLOCK in a circadian manner.
Function Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
Protein Name Inosine-5'-Monophosphate Dehydrogenase 2
Imp Dehydrogenase 2
Impd 2
Impdh 2
Inosine-5'-Monophosphate Dehydrogenase Type Ii
Imp Dehydrogenase Ii
Impdh-Ii
Database Links Reactome: R-HSA-6798695
Reactome: R-HSA-73817
Reactome: R-HSA-9679191
Reactome: R-HSA-9748787
Cellular Localisation Cytoplasm
Nucleus
Cytosol
Can Form Fiber-Like Subcellular Structures Termed 'Cytoophidia' In Response To Intracellular Guanine-Nucleotide Depletion
Alternative ELISA Names Inosine-5'-Monophosphate Dehydrogenase 2 ELISA kit
Imp Dehydrogenase 2 ELISA kit
Impd 2 ELISA kit
Impdh 2 ELISA kit
Inosine-5'-Monophosphate Dehydrogenase Type Ii ELISA kit
Imp Dehydrogenase Ii ELISA kit
Impdh-Ii ELISA kit
IMPDH2 ELISA kit
IMPD2 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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