产品详情

  • 产品名称：Anti-CCAR1 antibody (645-695) {Biotin} (STJ500385)

  • 产品型号：STJ500385-100
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CCAR1 antibody (645-695) {Biotin} (STJ500385)
详情介绍：
Host: Rabbit
Applications: ELISA/IHC/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CCAR1 (645-695) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Biotin
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.5 µg/µl
Dilution Range: WB: 1:500
ELISA: 1:10, 000
IP: 1:150
IHC: 1:50-1:150
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: CCAR1
Gene ID: 55749
Uniprot ID: CCAR1_HUMAN
Immunogen Region: 645-695
Immunogen: Synthetic peptide taken within amino acid region 645-695 on human Cell division cycle and apoptosis regulator protein 1.
Tissue Specificity Expressed in various epithelial cancer cell lines, including breast, colon, prostate, pancreatic and leukemia. Expression is regulated by growth factors.
Function Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation. May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation. In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells. Can act as a both a coactivator and corepressor of AR-mediated transcription. Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites. May play an important role in the growth and tumorigenesis of prostate cancer cells.
Protein Name Cell Division Cycle And Apoptosis Regulator Protein 1
Cell Cycle And Apoptosis Regulatory Protein 1
Carp-1
Death Inducer With Sap Domain
Database Links Reactome: R-HSA-72163
Cellular Localisation Cytoplasm
Perinuclear Region
Alternative Antibody Names Anti-Cell Division Cycle And Apoptosis Regulator Protein 1 antibody
Anti-Cell Cycle And Apoptosis Regulatory Protein 1 antibody
Anti-Carp-1 antibody
Anti-Death Inducer With Sap Domain antibody
Anti-CCAR1 antibody
Anti-CARP1 antibody
Anti-DIS antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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