产品详情

  • 产品名称：Human IL15 (Interleukin 15) Sandwich ELISA Kit (STJE0007081)

  • 产品型号：STJE0007081
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human IL15 (Interleukin 15) Sandwich ELISA Kit (STJE0007081)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 6.8pg/mL
Detection Limit: 15.6-1000pg/mL
Short Description: This IL15 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: IL15
Gene ID: 3600
Uniprot ID: IL15_HUMAN
Sample Type: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Tissue Specificity Most abundant in placenta and skeletal muscle. It is also detected in the heart, lung, liver and kidney. IL15-S21AA is preferentially expressed in tissues such as testis and thymus.
Post Translational Modifications
Function Cytokine that plays a major role in the development of inflammatory and protective immune responses to microbial invaders and parasites by modulating immune cells of both the innate and adaptive immune systems. Stimulates the proliferation of natural killer cells, T-cells and B-cells and promotes the secretion of several cytokines. In monocytes, induces the production of IL8 and monocyte chemotactic protein 1/CCL2, two chemokines that attract neutrophils and monocytes respectively to sites of infection. Unlike most cytokines, which are secreted in soluble form, IL15 is expressed in association with its high affinity IL15RA on the surface of IL15-producing cells and delivers signals to target cells that express IL2RB and IL2RG receptor subunits. Binding to its receptor triggers the phosphorylation of JAK1 and JAK3 and the recruitment and subsequent phosphorylation of signal transducer and activator of transcription-3/STAT3 and STAT5. In mast cells, induces the rapid tyrosine phosphorylation of STAT6 and thereby controls mast cell survival and release of cytokines such as IL4.
Protein Name Interleukin-15
Il-15
Database Links Reactome: R-HSA-8983432
Cellular Localisation Isoform Il15-S48aa: Secreted
Isoform Il15-S21aa: Cytoplasm
Nucleus
Il15-S21aa Is Not Secreted
But Rather Is Stored Intracellularly
Appearing In The Nucleus And Cytoplasmic Components
Alternative ELISA Names Interleukin-15 ELISA kit
Il-15 ELISA kit
IL15 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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