产品详情

  • 产品名称：Human IL10Ra (Interleukin 10 Receptor Alpha) Sandwich ELISA Kit (STJE0009749)

  • 产品型号：STJE0009749
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human IL10Ra (Interleukin 10 Receptor Alpha) Sandwich ELISA Kit (STJE0009749)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 13.8pg/mL
Detection Limit: 31.2-2000pg/mL
Short Description: This IL10Ra Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: IL10RA
Gene ID: 3587
Uniprot ID: I10R1_HUMAN
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Primarily expressed in hematopoetic cells including B-cells, T-cells, NK cells, monocytes and macrophages. Not expressed in non-hematopoetic cells such as fibroblasts or endothelial cells.
Post Translational Modifications Phosphorylated. Phosphorylation of the cytoplasmic tail induced STAT3 activation. Ubiquitinated by BTRC.ubiquitination leads to endocytosis and subsequent degradation of IL10RA.
Function Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well. In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively associated with IL10RA and IL10RB respectively. These kinases then phosphorylate specific tyrosine residues in the intracellular domain in IL10RA leading to the recruitment and subsequent phosphorylation of STAT3. Once phosphorylated, STAT3 homodimerizes, translocates to the nucleus and activates the expression of anti-inflammatory genes. In addition, IL10RA-mediated activation of STAT3 inhibits starvation-induced autophagy.
Protein Name Interleukin-10 Receptor Subunit Alpha
Il-10 Receptor Subunit Alpha
Il-10r Subunit Alpha
Il-10ra
Cdw210a
Interleukin-10 Receptor Subunit 1
Il-10r Subunit 1
Il-10r1
Cd Antigen Cd210
Database Links Reactome: R-HSA-6783783
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Cytoplasm
Alternative ELISA Names Interleukin-10 Receptor Subunit Alpha ELISA kit
Il-10 Receptor Subunit Alpha ELISA kit
Il-10r Subunit Alpha ELISA kit
Il-10ra ELISA kit
Cdw210a ELISA kit
Interleukin-10 Receptor Subunit 1 ELISA kit
Il-10r Subunit 1 ELISA kit
Il-10r1 ELISA kit
Cd Antigen Cd210 ELISA kit
IL10RA ELISA kit
IL10R ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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