产品详情

  • 产品名称：Anti-CASQ2 antibody (20-399) (STJ116447)

  • 产品型号：STJ116447
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CASQ2 antibody (20-399) (STJ116447)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CASQ2 (20-399) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CASQ2
Gene ID: 845
Uniprot ID: CASQ2_HUMAN
Immunogen Region: 20-399
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 20-399 of human CASQ2 (NP_001223.2).
Immunogen Sequence: EEGLNFPTYDGKDRVVSLSE KNFKQVLKKYDLLCLYYHEP VSSDKVTQKQFQLKEIVLEL VAQVLEHKAIGFVMVDAKKE AKLAKKLGFDEEGSLYILKG DRTIEFDGEFAADVLVEFLL DLIEDPVEIISSKLEVQAFE RIEDYIKLIGFFKSEDSEYY KAFEEAAEHFQPYIKFFATF DKGVAKKLSLKMNEVDFYEP FMDEPIAIPNKPYTEEELVE FVKEHQRPTLRRLRPEEMF
Post Translational Modifications Phosphorylation in the C-terminus, probably by CK2, moderately increases calcium buffering capacity. N-glycosylated.
Function Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2.this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.
Protein Name Calsequestrin-2
Calsequestrin - Cardiac Muscle Isoform
Database Links Reactome: R-HSA-2672351
Reactome: R-HSA-5578775
Cellular Localisation Sarcoplasmic Reticulum Lumen
This Isoform Of Calsequestrin Occurs In The Sarcoplasmic Reticulum's Terminal Cisternae Luminal Spaces Of Cardiac And Slow Skeletal Muscle Cells
Alternative Antibody Names Anti-Calsequestrin-2 antibody
Anti-Calsequestrin - Cardiac Muscle Isoform antibody
Anti-CASQ2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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