产品详情

  • 产品名称：Anti-CANX antibody (500-592) (STJ118079)

  • 产品型号：STJ118079
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CANX antibody (500-592) (STJ118079)
详情介绍：
Host: Rabbit
Applications: WB/IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CANX (500-592) is suitable for use in Western Blot and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CANX
Gene ID: 821
Uniprot ID: CALX_HUMAN
Immunogen Region: 500-592
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 500-592 of human Calnexin (NP_001737.1).
Immunogen Sequence: LFCCSGKKQTSGMEYKKTDA PQPDVKEEEEEKEEEKDKGD EEEEGEEKLEEKQKSDAEED GGTVSQEEEDRKPKAEEDEI LNRSPRNRKPRRE
Post Translational Modifications Phosphorylated at Ser-564 by MAPK3/ERK1. Phosphorylation by MAPK3/ERK1 increases its association with ribosomes. Palmitoylation by DHHC6 leads to the preferential localization to the perinuclear rough ER. It mediates the association of calnexin with the ribosome-translocon complex (RTC) which is required for efficient folding of glycosylated proteins. Ubiquitinated, leading to proteasomal degradation. Probably ubiquitinated by ZNRF4.
Function Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse.
Protein Name Calnexin
Ip90
Major Histocompatibility Complex Class I Antigen-Binding Protein P88
P90
Database Links Reactome: R-HSA-168316
Reactome: R-HSA-2132295
Reactome: R-HSA-8984722
Reactome: R-HSA-901042
Reactome: R-HSA-9020956
Reactome: R-HSA-9683686
Reactome: R-HSA-9694548
Reactome: R-HSA-983170
Cellular Localisation Endoplasmic Reticulum Membrane
Single-Pass Type I Membrane Protein
Endoplasmic Reticulum
Melanosome
Identified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv
The Palmitoylated Form Preferentially Localizes To The Perinuclear Rough Er
Alternative Antibody Names Anti-Calnexin antibody
Anti-Ip90 antibody
Anti-Major Histocompatibility Complex Class I Antigen-Binding Protein P88 antibody
Anti-P90 antibody
Anti-CANX antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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