产品详情

  • 产品名称：Anti-ATG4D antibody (Internal) (STJ71865)

  • 产品型号：STJ71865-100
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-ATG4D antibody (Internal) (STJ71865)
详情介绍：
Host: Goat
Applications: Pep-ELISA/IHC
Reactivity: Human/Mouse/Rat/Dog/Pig
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-ATG4D (Internal) is suitable for use in ELISA and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: IHC-2.5µg/ml
ELISA-antibody detection limit dilution 1:32000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: ATG4D
Gene ID: 84971
Uniprot ID: ATG4D_HUMAN
Immunogen Region: Internal
Accession Number: NP_116274.3
Immunogen Sequence: CSQLAQPTLRLPRT
Post Translational Modifications Cleaved by CASP3 during apoptosis which leads to increased activity. The cleavage by CASP3 reveals a cryptic mitochondrial targeting sequence immediately downstream of their canonical caspase cleavage sites which leads to mitochondrial import of the protein.
Function Cysteine protease ATG4D: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins. The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. In addition to the protease activity, also mediates delipidation of ATG8 family proteins. Catalyzes delipidation of PE-conjugated forms of ATG8 proteins during macroautophagy. Also involved in non-canonical autophagy, a parallel pathway involving conjugation of ATG8 proteins to single membranes at endolysosomal compartments, by catalyzing delipidation of ATG8 proteins conjugated to phosphatidylserine (PS). ATG4D plays a role in the autophagy-mediated neuronal homeostasis in the central nervous system. Compared to other members of the family (ATG4A, ATG4B or ATG4C), constitutes the major protein for the delipidation activity, while it promotes weak proteolytic activation of ATG8 proteins. Involved in phagophore growth during mitophagy independently of its protease activity and of ATG8 proteins: acts by regulating ATG9A trafficking to mitochondria and promoting phagophore-endoplasmic reticulum contacts during the lipid transfer phase of mitophagy. Cysteine protease ATG4D, mitochondrial: Plays a role as an autophagy regulator that links mitochondrial dysfunction with apoptosis. The mitochondrial import of ATG4D during cellular stress and differentiation may play important roles in the regulation of mitochondrial physiology, ROS, mitophagy and cell viability.
Protein Name Cysteine Protease Atg4d
Aut-Like 4 Cysteine Endopeptidase
Autophagy-Related Cysteine Endopeptidase 4
Autophagin-4
Autophagy-Related Protein 4 Homolog D
Hsapg4d Cleaved Into - Cysteine Protease Atg4d - Mitochondrial
Database Links Reactome: R-HSA-1632852
Cellular Localisation Cysteine Protease Atg4d: Cytoplasm
Cysteine Protease Atg4d
Mitochondrial: Cytoplasm
Mitochondrion Matrix
Imported Into Mitochondrial Matrix After Cleavage By Casp3 During Oxidative Stress And Cell Death
Alternative Antibody Names Anti-Cysteine Protease Atg4d antibody
Anti-Aut-Like 4 Cysteine Endopeptidase antibody
Anti-Autophagy-Related Cysteine Endopeptidase 4 antibody
Anti-Autophagin-4 antibody
Anti-Autophagy-Related Protein 4 Homolog D antibody
Anti-Hsapg4d Cleaved Into - Cysteine Protease Atg4d - Mitochondrial antibody
Anti-ATG4D antibody
Anti-APG4D antibody
Anti-AUTL4 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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