产品详情

  • 产品名称：Anti-CAND1 antibody (750-980) (STJ116499)

  • 产品型号：STJ116499
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-CAND1 antibody (750-980) (STJ116499)
详情介绍：
Host: Rabbit
Applications: WB/IHC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CAND1 (750-980) is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IHC-P 1:50-1:100
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CAND1
Gene ID: 55832
Uniprot ID: CAND1_HUMAN
Immunogen Region: 750-980
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 750-980 of human CAND1 (NP_060918.2).
Immunogen Sequence: GALSAMLDFFQALVVTGTNN LGYMDLLRMLTGPVYSQSTA LTHKQSYYSIAKCVAALTRA CPKEGPAVVGQFIQDVKNSR STDSIRLLALLSLGEVGHHI DLSGQLELKSVILEAFSSPS EEVKSAASYALGSISVGNLP EYLPFVLQEITSQPKRQYLL LHSLKEIISSASVVGLKPYV ENIWALLLKHCECAEEGTRN VVAECLGKLTLIDPETLLPR LKGYLISGSSY
Function Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes.
Protein Name Cullin-Associated Nedd8-Dissociated Protein 1
Cullin-Associated And Neddylation-Dissociated Protein 1
Tbp-Interacting Protein Of 120 Kda A
Tbp-Interacting Protein 120a
P120 Cand1
Database Links Reactome: R-HSA-6798695
Reactome: R-HSA-8951664
Reactome: R-HSA-917937
Cellular Localisation Cytoplasm
Nucleus
Predominantly Cytoplasmic
Alternative Antibody Names Anti-Cullin-Associated Nedd8-Dissociated Protein 1 antibody
Anti-Cullin-Associated And Neddylation-Dissociated Protein 1 antibody
Anti-Tbp-Interacting Protein Of 120 Kda A antibody
Anti-Tbp-Interacting Protein 120a antibody
Anti-P120 Cand1 antibody
Anti-CAND1 antibody
Anti-KIAA0829 antibody
Anti-TIP120 antibody
Anti-TIP120A antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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