产品详情

  • 产品名称：Human HNRPK (Heterogeneous Nuclear Ribonucleoprotein K) Sandwich ELISA Kit (STJE0009486)

  • 产品型号：STJE0009486
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human HNRPK (Heterogeneous Nuclear Ribonucleoprotein K) Sandwich ELISA Kit (STJE0009486)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.107ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This HNRPK Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: HNRNPK
Gene ID: 3190
Uniprot ID: HNRPK_HUMAN
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity
Post Translational Modifications Arg-296 and Arg-299 are dimethylated, probably to asymmetric dimethylarginine. Sumoylated by CBX4. Sumoylation is increased upon DNA damage, such as that produced by doxorubicin, etoposide, UV light and camptothecin, due to enhanced CBX4 phosphorylation by HIPK2 under these conditions. Ubiquitinated by MDM2. Doxorubicin treatment does not affect monoubiquitination, but slightly decreases HNRNPK poly-ubiquitination. O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.
Function One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation.
Protein Name Heterogeneous Nuclear Ribonucleoprotein K
Hnrnp K
Transformation Up-Regulated Nuclear Protein
Tunp
Database Links Reactome: R-HSA-4570464
Reactome: R-HSA-72163
Reactome: R-HSA-72203
Reactome: R-HSA-9610379
Cellular Localisation Cytoplasm
Nucleus
Nucleoplasm
Cell Projection
Podosome
Recruited To P53/Tp53-Responsive Promoters
In The Presence Of Functional P53/Tp53
In Case Of Asfv Infection
There Is A Shift In The Localization Which Becomes Predominantly Nuclear
Alternative ELISA Names Heterogeneous Nuclear Ribonucleoprotein K ELISA kit
Hnrnp K ELISA kit
Transformation Up-Regulated Nuclear Protein ELISA kit
Tunp ELISA kit
HNRNPK ELISA kit
HNRPK ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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