产品详情

  • 产品名称：Anti-ASTL antibody (24-431) (STJ117183)

  • 产品型号：STJ117183
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-ASTL antibody (24-431) (STJ117183)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-ASTL (24-431) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ASTL
Gene ID: 431705
Uniprot ID: ASTL_HUMAN
Immunogen Region: 24-431
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 24-431 of human ASTL (NP_001002036.3).
Immunogen Sequence: APLASSCAGACGTSFPDGLT PEGTQASGDKDIPAINQGLI LEETPESSFLIEGDIIRPSP FRLLSATSNKWPMGGSGVVE VPFLLSSKYDEPSRQVILEA LAEFERSTCIRFVTYQDQRD FISIIPMYGCFSSVGRSGGM QVVSLAPTCLQKGRGIVLHE LMHVLGFWHEHTRADRDRYI RVNWNEILPGFEINFIKSQS SNMLTPYDYSSVMHYGRLAF SRRGLPTITPLWAPSVHIG
Function Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. Plays a role in the polyspermy inhibition. Probably acts as a protease for the post-fertilization cleavage of ZP2. Cleaves the sperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis, rendering the zona pellucida unable to support further sperm binding.
Protein Name Astacin-Like Metalloendopeptidase
Oocyte Astacin
Ovastacin
Zp2-Proteinase
Cellular Localisation Cytoplasm
Cell Membrane
Cytoplasmic Vesicle
Secretory Vesicle
Cortical Granule
Probably Exocytosed From Cortical Granules During Post-Fertilization
Detected Throughout The Ooplasm Of Germinal Vesicle Stage Oocytes In Early Bilaminar Secondary Follicles At Postnatal (Pn) Day 3
Detected In The Microvillar Domain Of The Oolemma In Arrested Ovulated Secondary Oocytes And In The First Polar Body Prior To Fertilization
Upon Fertilization
Detected In The Perivitelline Space (Pvs) And Occasionally On The Oolemma In 2-Cell Through Morulae Stages
Colocalizes With Spaca3 At The Microvillar Domain Of The Oolemma And In The Perivitelline Space (Pvs)
Alternative Antibody Names Anti-Astacin-Like Metalloendopeptidase antibody
Anti-Oocyte Astacin antibody
Anti-Ovastacin antibody
Anti-Zp2-Proteinase antibody
Anti-ASTL antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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