产品详情

  • 产品名称：Human GbA (Glucosidase Beta, Acid) Sandwich ELISA Kit Ready-To-Use (STJE0015465)

  • 产品型号：STJE0015465
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human GbA (Glucosidase Beta, Acid) Sandwich ELISA Kit Ready-To-Use (STJE0015465)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.59ng/mL
Detection Limit: 1.56-100ng/mL
Short Description: This GbA Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: GBA1
Gene ID: 2629
Uniprot ID: GBA1_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: serum, plasma, tissue homogenates or other biological fluids.
Tissue Specificity
Post Translational Modifications
Function Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramides/GlcCers (such as beta-D-glucosyl-(11')-N-acylsphing-4-enine) into free ceramides (such as N-acylsphing-4-enine) and glucose. Plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates in the PKC-activated salvage pathway of ceramide formation. Catalyzes the glucosylation of cholesterol, through a transglucosylation reaction where glucose is transferred from GlcCer to cholesterol. GlcCer containing mono-unsaturated fatty acids (such as beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4-enine) are preferred as glucose donors for cholesterol glucosylation when compared with GlcCer containing same chain length of saturated fatty acids (such as beta-D-glucosyl-N-octadecanoyl-sphing-4-enine). Under specific conditions, may alternatively catalyze the reverse reaction, transferring glucose from cholesteryl 3-beta-D-glucoside to ceramide (Probable). Can also hydrolyze cholesteryl 3-beta-D-glucoside producing glucose and cholesterol. Catalyzes the hydrolysis of galactosylceramides/GalCers (such as beta-D-galactosyl-(11')-N-acylsphing-4-enine), as well as the transfer of galactose between GalCers and cholesterol in vitro, but with lower activity than with GlcCers. Contrary to GlcCer and GalCer, xylosylceramide/XylCer (such as beta-D-xyosyl-(11')-N-acylsphing-4-enine) is not a good substrate for hydrolysis, however it is a good xylose donor for transxylosylation activity to form cholesteryl 3-beta-D-xyloside.
Protein Name Lysosomal Acid Glucosylceramidase
Lysosomal Acid Gcase
Acid Beta-Glucosidase
Alglucerase
Beta-Glucocerebrosidase
Beta-Gc
Beta-Glucosylceramidase 1
Cholesterol Glucosyltransferase
Sgtase
Cholesteryl-Beta-Glucosidase
D-Glucosyl-N-Acylsphingosine Glucohydrolase
Glucosylceramidase Beta 1
Imiglucerase
Lysosomal Cholesterol Glycosyltransferase
Lysosomal Galactosylceramidase
Lysosomal Glycosylceramidase
Database Links Reactome: R-HSA-1660662
Reactome: R-HSA-390471
Cellular Localisation Lysosome Membrane
Peripheral Membrane Protein
Lumenal Side
Interaction With Saposin-C Promotes Membrane Association
Targeting To Lysosomes Occurs Through An Alternative Mpr-Independent Mechanism Via Scarb2
Alternative ELISA Names Lysosomal Acid Glucosylceramidase ELISA kit
Lysosomal Acid Gcase ELISA kit
Acid Beta-Glucosidase ELISA kit
Alglucerase ELISA kit
Beta-Glucocerebrosidase ELISA kit
Beta-Gc ELISA kit
Beta-Glucosylceramidase 1 ELISA kit
Cholesterol Glucosyltransferase ELISA kit
Sgtase ELISA kit
Cholesteryl-Beta-Glucosidase ELISA kit
D-Glucosyl-N-Acylsphingosine Glucohydrolase ELISA kit
Glucosylceramidase Beta 1 ELISA kit
Imiglucerase ELISA kit
Lysosomal Cholesterol Glycosyltransferase ELISA kit
Lysosomal Galactosylceramidase ELISA kit
Lysosomal Glycosylceramidase ELISA kit
GBA1 ELISA kit
GBA ELISA kit
GC ELISA kit
GLUC ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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