产品详情

  • 产品名称：Anti-BMP7 antibody (124-173 aa) (STJ91868)

  • 产品型号：STJ91868
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-BMP7 antibody (124-173 aa) (STJ91868)
详情介绍：
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Bone morphogenetic protein 7 (124-173 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:40000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: BMP7
Gene ID: 655
Uniprot ID: BMP7_HUMAN
Immunogen Region: 124-173 aa
Specificity: BMP-7 Polyclonal Antibody detects endogenous levels of BMP-7 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human BMP-7 at the amino acid range 124-173
Post Translational Modifications Several N-termini starting at positions 293, 300, 315 and 316 have been identified by direct sequencing resulting in secretion of different mature forms.
Function Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including embryogenesis, hematopoiesis, neurogenesis and skeletal morphogenesis. Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2A. Once all three components are bound together in a complex at the cell surface, ACVR2A phosphorylates and activates ACVR1. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. For specific functions such as growth cone collapse in developing spinal neurons and chemotaxis of monocytes, uses also BMPR2 as type II receptor. Can also signal through non-canonical pathways such as P38 MAP kinase signaling cascade that promotes brown adipocyte differentiation through activation of target genes, including members of the SOX family of transcription factors. Promotes the expression of HAMP, this is repressed by its interaction with ERFE.
Protein Name Bone Morphogenetic Protein 7
Bmp-7
Osteogenic Protein 1
Op-1
Eptotermin Alfa
Database Links Reactome: R-HSA-2129379
Cellular Localisation Secreted
Alternative Antibody Names Anti-Bone Morphogenetic Protein 7 antibody
Anti-Bmp-7 antibody
Anti-Osteogenic Protein 1 antibody
Anti-Op-1 antibody
Anti-Eptotermin Alfa antibody
Anti-BMP7 antibody
Anti-OP1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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