产品详情

  • 产品名称：Human FADS1 (Fatty Acid Desaturase 1) Sandwich ELISA Kit Ready-To-Use (STJE0015148)

  • 产品型号：STJE0015148
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human FADS1 (Fatty Acid Desaturase 1) Sandwich ELISA Kit Ready-To-Use (STJE0015148)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 33pg/mL
Detection Limit: 78.1-5000pg/mL
Short Description: This FADS1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: FADS1
Gene ID: 3992
Uniprot ID: FADS1_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: serum, plasma, tissue homogenates or other biological fluids.
Tissue Specificity Widely expressed, with highest levels in liver, brain, adrenal gland and heart. Highly expressed in fetal liver and brain.
Post Translational Modifications
Function Isoform 1: Acts as a front-end fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 5 located between a preexisting double bond and the carboxyl end of the fatty acyl chain. Involved in biosesynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors. Specifically, desaturates dihomo-gamma-linoleoate (DGLA) (20:3n-6) and eicosatetraenoate (ETA) (20:4n-3) to generate arachidonate (AA) (20:4n-6) and eicosapentaenoate (EPA) (20:5n-3), respectively. As a rate limiting enzyme for DGLA (20:3n-6) and AA (20:4n-6)-derived eicosanoid biosesynthesis, controls the metabolism of inflammatory lipids like prostaglandin E2, critical for efficient acute inflammatory response and maintenance of epithelium homeostasis. Contributes to membrane phospholipid biosesynthesis by providing AA (20:4n-6) as a major acyl chain esterified into phospholipids. In particular, regulates phosphatidylinositol-4,5-bisphosphate levels, modulating inflammatory cytokine production in T-cells. Also desaturates (11E)-octadecenoate (trans-vaccenoate)(18:1n-9), a metabolite in the biohydrogenation pathway of LA (18:2n-6). Isoform 2: Does not exhibit any catalytic activity toward 20:3n-6, but it may enhance FADS2 activity.
Protein Name Acyl-Coa
8-3-Desaturase
Delta(5 Fatty Acid Desaturase
D5d
Delta(5 Desaturase
Delta-5 Desaturase
Fatty Acid Desaturase 1
Database Links Reactome: R-HSA-1989781
Reactome: R-HSA-2046105
Reactome: R-HSA-2046106
Cellular Localisation Isoform 1: Endoplasmic Reticulum Membrane
Multi-Pass Membrane Protein
Mitochondrion
Isoform 2: Endoplasmic Reticulum Membrane
Alternative ELISA Names Acyl-Coa ELISA kit
8-3-Desaturase ELISA kit
Delta(5 Fatty Acid Desaturase ELISA kit
D5d ELISA kit
Delta(5 Desaturase ELISA kit
Delta-5 Desaturase ELISA kit
Fatty Acid Desaturase 1 ELISA kit
FADS1 ELISA kit
FADSD5 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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