产品详情

  • 产品名称：Human EXOSC2 (Exosome Component 2) Sandwich ELISA Kit (STJE0008719)

  • 产品型号：STJE0008719
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human EXOSC2 (Exosome Component 2) Sandwich ELISA Kit (STJE0008719)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.061ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This EXOSC2 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: EXOSC2
Gene ID: 23404
Uniprot ID: EXOS2_HUMAN
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity
Post Translational Modifications
Function Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC2 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC4 and EXOSC7.
Protein Name Exosome Complex Component Rrp4
Exosome Component 2
Ribosomal Rna-Processing Protein 4
Database Links Reactome: R-HSA-380994
Reactome: R-HSA-429958
Reactome: R-HSA-450385
Reactome: R-HSA-450513
Reactome: R-HSA-450604
Reactome: R-HSA-6791226
Cellular Localisation Cytoplasm
Nucleus
Nucleolus
Alternative ELISA Names Exosome Complex Component Rrp4 ELISA kit
Exosome Component 2 ELISA kit
Ribosomal Rna-Processing Protein 4 ELISA kit
EXOSC2 ELISA kit
RRP4 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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